chemical inhibits protein has role has role tertiary carboxamide onalespib 409.23654 PMID:27156227 PMID:27321499 PMID:21538821 PMID:23186098 PMID:27673365 PMID:25349308 A member of the class of isoindoles that is isoindole in which the amino group has been acylated by a 2,4-dihydroxy-5-isopropylbenzoyl group and in which position 5 of the isoidole moiety has been substituted by a (4-methylpiperazin-1-yl)methyl group. A second-generation Hsp90 inhibitor. chebi_ontology PMID:28679777 PMID:25336693 409.522 PMID:27197266 Reference: PMID: 33330614 PMID:26248657 PMID:26452257 PMCID:PMC4638428 PMID:22714264 (2,4-dihydroxy-5-isopropylphenyl){5-[(4-methylpiperazin-1-yl)methyl]-1,3-dihydro-2H-isoindol-2-yl}methanone (2,4-dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl)methanone onalespib AT-13387 PMID:22181674 PMID:31638190 IFRGXKKQHBVPCQ-UHFFFAOYSA-N CAS:912999-49-6 AT13387 PDBeChem:XJX Reaxys:18536397 KEGG:D10719 0 DrugBank:DB06306 InChI=1S/C24H31N3O3/c1-16(2)20-11-21(23(29)12-22(20)28)24(30)27-14-18-5-4-17(10-19(18)15-27)13-26-8-6-25(3)7-9-26/h4-5,10-12,16,28-29H,6-9,13-15H2,1-3H3 C(=O)(C1=CC(=C(C=C1O)O)C(C)C)N2CC3=C(C2)C=CC(=C3)CN4CCN(CC4)C onalespibum AT 13387 C24H31N3O3 CHEBI:140592 PMID:24156782 PMID:26627081 PMID:26082332 PMID:20662534 benzamides isoindoles resorcinols inhibitor antineoplastic agent N-alkylpiperazine Hsp90 inhibitor endoplasmin