chemical inhibits protein chemical inhibits in vitro replication of virus has role has role primary carboxamide gilteritinib DrugBank:DB12141 552.35364 0 gilteritinibum PMID:31069015 PMID:31454267 PMID:31469903 PMID:30936061 PMCID:PMC6817455 PMID:31665578 KEGG:D10709 InChI=1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34) PMID:30039554 PMID:31528345 PMID: 32366720 GYQYAJJFPNQOOW-UHFFFAOYSA-N ASP2215 PMID:31320594 ASP 2215 ASP-2215 6-ethyl-3-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino}-5-(tetrahydro-2H-pyran-4-ylamino)pyrazine-2-carboxamide gilteritinib 6-ethyl-3-((3-methoxy-4-(4-(4-methyl-1-piperazinyl)-1-piperidinyl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)-2-pyrazinecarboxamide PMID:29498296 Wikipedia:Gilteritinib PMID:26279055 CCC1=NC(C(=O)N)=C(NC2=CC=C(N3CCC(CC3)N4CCN(C)CC4)C(OC)=C2)N=C1NC5CCOCC5 PMID:31122910 6-ethyl-3-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino}-5-[(oxan-4-yl)amino]pyrazine-2-carboxamide Xospata PMID:28516360 PMID:30721452 https://www.drugbank.ca/drugs/DB12141 PMID:31692922 PMID:28645776 C29H44N8O3 552.724 PMID:30514344 A member of the class of pyrazines that is pyrazine-2-carboxamide which is substituted by {3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}nitrilo, (oxan-4-yl)nitrilo and ethyl groups at positions 3,5 and 6, respectively. It is a potent inhibitor of FLT3 and AXL tyrosine kinase receptors (IC50 = 0.29 nM and 0.73 nM, respectively). Approved by the FDA for the treatment of acute myeloid leukemia in patients who have a FLT3 gene mutation. chebi_ontology CHEBI:145372 PMID:27908881 PMID:31203997 CAS:1254053-43-4 monomethoxybenzene piperidines aromatic amine antineoplastic agent pyrazines N-methylpiperazine oxanes secondary amino compound EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor apoptosis inducer Severe acute respiratory syndrome-related coronavirus tyrosine-protein kinase receptor UFO (human) receptor-type tyrosine-protein kinase FLT3 (human) ALK tyrosine kinase receptor (human)