chemical inhibits protein chemical inhibits in vivo replication of virus chemical inhibits in vitro replication of virus has role has role has functional parent remdesivir PMID:28124907 A carboxylic ester resulting from the formal condensation of the carboxy group of N-[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]-L-alanine with the hydroxy group of 2-ethylbutan-1-ol. A broad-spectrum antiviral prodrug with potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. It is currently in Phase III clinical trials for the treatment of Covid-19 in adults. remdesivirum GS-5734 PMID: 30849247; PMID: 32251768; PMID: 21297106; PMID: 28659436; PMID: 32054787 PMID:32020029 PMID:30987343 InChI=1S/C27H35N6O8P/c1-4-18(5-2)13-38-26(36)17(3)32-42(37,41-19-9-7-6-8-10-19)39-14-21-23(34)24(35)27(15-28,40-21)22-12-11-20-25(29)30-16-31-33(20)22/h6-12,16-18,21,23-24,34-35H,4-5,13-14H2,1-3H3,(H,32,37)(H2,29,30,31)/t17-,21+,23+,24+,27-,42-/m0/s1 PMID:30275474 chebi_ontology PubChem CID: 121304016 PMID:31233808 RWWYLEGWBNMMLJ-YSOARWBDSA-N PMID:32094225 KEGG:D11472 602.22540 CAS:1809249-37-3 [C@]1(O[C@@H]([C@H]([C@H]1O)O)CO[P@@](N[C@H](C(OCC(CC)CC)=O)C)(OC=2C=CC=CC2)=O)(C#N)C=3N4N=CN=C(C4=CC3)N 0 DrugBank:DB14761 PMID:32152082 C27H35N6O8P CHEBI:145994 PMID: 30849247; PMID: 32251768; PMID: 21297106 PMID:31142680 PMID:28659436 PMID:32145386 GS 5734 (2S)-2-{(2R,3S,4R,5R)-[5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phenoxy-(S)-phosphorylamino}propionic acid 2-ethyl-butyl ester PMID:26934220 remdesivir 602.585 PMID:32147516 https://www.drugbank.ca/drugs/DB14761 PMID:29511076 PMID:32054787 PMID:31924756 GS5734 PMID:28262699 PMCID:PMC5630887 2-ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate 2-ethylbutyl N-[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]-L-alaninate https://en.wikipedia.org/wiki/Remdesivir Wikipedia:Remdesivir https://pubchem.ncbi.nlm.nih.gov/compound/121304016 GS-441524 anticoronaviral agent nitrile phosphoramidate ester carboxylic ester aromatic amine antiviral drug C-nucleoside prodrug pyrrolotriazine chemical role against SARS-CoV-2 replication Middle East respiratory syndrome-related coronavirus SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome-related coronavirus Replicase polyprotein 1ab (SARS-CoV) RNA-directed RNA polymerase L (Zaire Ebola virus)