has role has role GS-441524 [C@]1(O[C@@H]([C@H]([C@H]1O)O)CO)(C#N)C=2N3N=CN=C(C3=CC2)N EVO 984 CAS:1191237-69-0 C12H13N5O4 A C-nucleoside analog that is (2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile substituted by a 4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl group at position 2. It is the active metabolite of remdesivir and exhibits a broad range of inhibitory activity against various RNA viruses including HCV, parainfluenza and SARS-CoV. PMID:22446091 InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1 chebi_ontology 291.09675 PMID:29778200 GS 441524 EVO-984 PMID:28124907 PMID:30755068 0 EVO984 (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile 291.267 BRDWIEOJOWJCLU-LTGWCKQJSA-N GS441524 CHEBI:147281 anticoronaviral agent nitrile antiviral agent aromatic amine C-nucleoside drug metabolite pyrrolotriazine