chemical inhibits in vitro replication of virus has role has role secondary carboxamide EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor SG85 InChI=1S/C35H46N4O8/c1-5-45-30(40)17-16-27(21-26-18-19-36-31(26)41)37-32(42)28(20-24-12-8-6-9-13-24)38-33(43)29(23-47-35(2,3)4)39-34(44)46-22-25-14-10-7-11-15-25/h6-17,26-29H,5,18-23H2,1-4H3,(H,36,41)(H,37,42)(H,38,43)(H,39,44)/b17-16+/t26-,27+,28-,29-/m0/s1 A secondary carboxamide resulting from the formal condensation of the carboxy group of N-[(benzyloxy)carbonyl]-O-tert-butyl-L-serine with the primary amino group of ethyl (2E,4S)-5-[(3S)-2-oxopyrrolidin-3-yl]-4-(L-phenylalanylamino)pent-2-enoate. It is a potent enterovirus 3C protease inhibitor with EC50 of 180 nM against enterovirus 71 (EV71) and 60 nM against human rhinovirus 14 in a live virus-cell-based assay. SG 85 CTAXDRJNQQBEIB-VCJIVHKYSA-N chebi_ontology N-[(benzyloxy)carbonyl]-O-tert-butyl-L-seryl-N-{(2S,3E)-5-ethoxy-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pent-3-en-2-yl}-L-phenylalaninamide PMID:25039866 CHEBI:147346 CAS:1575662-24-6 C35H46N4O8 0 PMID: 25039866; PMID: 27344959 650.773 PMID:23388726 C=1C(=CC=CC1)COC(N[C@H](C(N[C@H](C(N[C@H](/C=C/C(OCC)=O)C[C@H]2C(NCC2)=O)=O)CC=3C=CC=CC3)=O)COC(C)(C)C)=O PMID:26055377 650.33156 SG-85 PMID:25199773 PMID:27668727 anticoronaviral agent antiviral agent ethyl ester ether enoate ester pyrrolidin-2-ones L-serine derivative L-phenylalanine derivative benzyl ester Middle East respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus