chemical modulates protein has role has role autophagy inducer secondary carboxamide nitrile AZ3451 PMID:34590836 PDBeChem:8UN PMID:29457894 AZ 3451 CAS:2100284-59-9 AZ-3451 0 PMID:28445455 571.475 Chemspider:59053349 PMID:31841119 C[C@@H](C1CCCCC1)N1C2=CC=C(C=C2N=C1C1=CC2=C(OCO2)C=C1Br)C(=O)NC1=CC=C(C=C1)C#N 2-(6-bromo-1,3-benzodioxol-5-yl)-N-(4-cyanophenyl)-1-[(1S)-1-cyclohexylethyl]-1H-benzimidazole-5-carboxamide A member of the class of benzimidazoles that is 1H-benzimidazole substituted by (1S)-1-cyclohexylethyl, 6-bromo-1,3-benzodioxol-5-yl, and 4-(cyanoanilino)acyl groups at positions 1, 2 and 5, respectively. It is an allosteric modulator of protease-activated receptor 2 (IC50 = 23 nM) and exhibits anti-osteoarthritis properties. chebi_ontology InChI=1S/C30H27BrN4O3/c1-18(20-5-3-2-4-6-20)35-26-12-9-21(30(36)33-22-10-7-19(16-32)8-11-22)13-25(26)34-29(35)23-14-27-28(15-24(23)31)38-17-37-27/h7-15,18,20H,2-6,17H2,1H3,(H,33,36)/t18-/m0/s1 PMID:33242065 CHEBI:189647 570.12665 PMID:29798827 Reference: PMID: 28445455 FJAOGFGHTPYADT-SFHVURJKSA-N C30H27BrN4O3 PMID:34307771 PAR2 negative allosteric modulator benzimidazoles organobromine compound benzodioxoles anti-inflammatory agent proteinase-activated receptor 2