chemical inhibits protein has role has role tertiary carboxamide PF-06446846 PMID:28323820 CHEBI:189659 C22H20ClN7O Chemspider:74849329 PMID:31867167 Reference: PMID: 28323820 N-(3-chloropyridin-2-yl)-N-[(3R)-piperidin-3-yl]-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)benzamide PMID:34359627 0 433.900 433.14179 PF-846 PMID:33801308 Patent:US9227956 A triazolopyridine that is 3H-[1,2,3]triazolo[4,5-b]pyridine substituted by a 4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}phenyl group at position 3. It is a potent inhibitor of PCSK9. CAS:1632250-49-7 PMID:33009412 PMID:31160784 ClC1=CC=CN=C1N([C@@H]1CCCNC1)C(=O)C1=CC=C(C=C1)N1N=NC2=CC=CN=C12 PDBeChem:MVM chebi_ontology PMID:29878763 PF 06446846 FDTXHWQFIXYHCL-QGZVFWFLSA-N PF-06446846 InChI=1S/C22H20ClN7O/c23-18-5-2-12-25-20(18)29(17-4-1-11-24-14-17)22(31)15-7-9-16(10-8-15)30-21-19(27-28-30)6-3-13-26-21/h2-3,5-10,12-13,17,24H,1,4,11,14H2/t17-/m1/s1 PF06446846 EC 3.4.21.61 (kexin) inhibitor benzamides piperidines inhibitor antilipemic drug monochloropyridine triazolopyridine 60S ribosomal protein L27