chemical inhibits protein has role has role has functional parent hexahydronaphthalenes delta-lactone polyketide mevastatin inhibitor antineoplastic agent fatty acid ester anticholesteremic drug (S)-2-methylbutyric acid lovastatin PMID:24093797 404.53964 PMID:11375168 Mevacor Mevinolin KEGG:D00359 ML-530B PDBeChem:803 Beilstein:3631989 CHEBI:40303 LOVASTATIN chebi_ontology Reaxys:4720754 CHEBI:40299 CAS:75330-75-5 Patent:CN103172602 0 CHEBI:6544 [H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC PMID:11483865 6alpha-methylcompactin C24H36O5 PMID:18642339 lovastatin (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate Patent:WO2013090461 A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom). HMDB:HMDB0014372 (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate PCZOHLXUXFIOCF-BXMDZJJMSA-N DrugBank:DB00227 Lovastatin 404.25627 2beta,6alpha-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone MK-803 PMID:7720768 Reference: PMID: 6933445 KNApSAcK:C00000547 Drug_Central:1612 InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1 Wikipedia:Lovastatin LINCS:LSM-2189 PMID:11389707 KEGG:C07074 prodrug Aspergillus metabolite statin (naturally occurring) 3-hydroxy-3-methylglutaryl-coenzyme A reductase