chemical inhibits protein chemical binds protein chemical inhibits in vitro replication of virus has role has role anticoronaviral agent geroprotector homodetic cyclic peptide metabolite immunosuppressive agent antifungal agent antirheumatic drug EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor cyclosporin A Cyclosporine CiteXplore:18790203 PMID:11442023 PMID:12050171 CiteXplore:16724420 PMID:14621732 Patent:US4117118 PMID:14743390 PMID:11278005 PMID:24134630 CiteXplore:17603747 chebi_ontology CiteXplore:18217899 CiteXplore:14682659 PMID:17117422 PMID:11079273 CiteXplore:11069928 Beilstein:3647785 PMID:17220244 InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1 PMID:16404634 Antibiotic S 7481F1 Wikipedia:Ciclosporin CiteXplore:15711594 PMID:15962181 https://www.drugbank.ca/drugs/DB00091 PMID:17603747 PMID:11256490 ChemIDplus:59865-13-3 CiteXplore:17220244 CiteXplore:11079273 CiteXplore:11058832 CiteXplore:12603598 PMID:15210365 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone Reaxys:3647785 1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine] 1202.61120 PMID:18790203 PMID:12929192 PMID:17083576 KNApSAcK:C00001517 PMID:11406057 Drug_Central:760 CiteXplore:15210365 CiteXplore:18076075 Cyclosporin A PMATZTZNYRCHOR-CGLBZJNRSA-N PMID:15711594 CiteXplore:16404634 Ciclosporin PMID:15811524 ciclosporinum PMID:17446460 PMID:14638917 CiteXplore:17192032 CiteXplore:16801218 PMID: 27478032; PMID: 27344959 PMID:21752960 CiteXplore:19282398 C62H111N11O12 CiteXplore:18359899 PMID:18076075 CiteXplore:12929192 30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone CiteXplore:11870366 CiteXplore:18975184 Sandimmune CiteXplore:11278005 CiteXplore:1566062 PMID:11080188 cyclosporin A PMID:15541012 PMID:15613074 PMID:17229932 CiteXplore:17446460 PMID:11481617 PMID:1566062 PMID:31144214 PMID:16724420 PMID:11315347 CiteXplore:18259730 PMID:18931077 CiteXplore:12761440 PMID:23620378 PMID:11069928 HMDB:HMDB0250682 Chemspider:4447449 A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle. CiteXplore:11370709 ciclosporin Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl) PMID:18583716 CiteXplore:15657176 CiteXplore:15626898 Neoral PMID:15383526 CiteXplore:11426833 PMID:34561200 CiteXplore:15030555 InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42+,43-,44+,45-,46+,47+,49+,50-,51+,52-/m1/s1 PMID:18191430 CiteXplore:16372476 CiteXplore:11256490 LINCS:LSM-1703 PMID:17265451 PMID:15175101 PMID:15306697 PMID:17032751 CiteXplore:18171316 CiteXplore:11493684 CiteXplore:11564166 PMID:18299432 C62H111N11O12 (R-[R*,R*-(E)])-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl) PMID:14682659 PMID:18975184 PMID:11870366 PMID:18259730 CC[C@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C PMID:14521916 CiteXplore:19589783 PMID:34561814 CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C PMID:16898534 PMID:11676831 PMID:19282398 Cyclosporine 3008 PMID:12761440 MetaCyc:CPD-20532 PMID:12950728 PMID:15657176 VSDB:1765 CiteXplore:14672695 PMID:11557554 LIPID_MAPS_instance:LMPK14000003 PMID:12021257 CiteXplore:11238591 CiteXplore:11315347 CiteXplore:15811524 CiteXplore:18818682 PMID:18818682 KEGG DRUG:D00184 InChIKey=PMATZTZNYRCHOR-VJRYSDSKSA-N CiteXplore:15383526 PMID:18597363 CiteXplore:12021257 KEGG:D00184 PMID:11058832 CiteXplore:14521916 CiteXplore:11529914 Gengraf 1201.84137 PMID:19589783 CiteXplore:11557554 CiteXplore:14638917 PMID:11529914 CiteXplore:17265451 CiteXplore:15962181 PMID:18217899 CiteXplore:14743390 PMID:11564166 CiteXplore:18597363 CiteXplore:12950728 PMID:15626898 PMID:11426833 CiteXplore:11442023 DrugBank:DB00091 PMID:12603598 KEGG:C05086 CiteXplore:14621732 CiteXplore:15175101 CAS:59865-13-3 CiteXplore:15306697 PMID:18171316 PMID:11493684 CiteXplore:18299432 KEGG COMPOUND:59865-13-3 CHEBI:63586 PMID:16372476 CiteXplore:11406057 CiteXplore:18191430 CiteXplore:17083576 CiteXplore:17117422 CiteXplore:15613074 CiteXplore:17229932 CiteXplore:11080188 CHEBI:91802 CiteXplore:18583716 CiteXplore:17032751 PMID:11370709 PMID:18359899 PMID:15030555 PMID:17192032 0 CHEBI:4031 CiteXplore:16898534 CiteXplore:11676831 PMID:11238591 CiteXplore:12050171 PMID:16801218 PMID:14672695 ciclosporine ciclosporina CiteXplore:18931077 CiteXplore:11481617 KEGG COMPOUND:C05086 CiteXplore:15541012 anti-asthmatic drug dermatologic drug carcinogenic agent Middle East respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus peptidyl-prolyl cis-trans isomerase F, mitochondrial (human) guided entry of tail-anchored proteins factor CAMLG (human) peptidyl-prolyl cis-trans isomerase A (human) calcineurin subunit B type 2 (human)