is bearer of is_bearer_of chemical inhibits in vivo replication of virus chemical inhibits in vitro replication of virus has role has role carbamate ester valine derivative HIV protease inhibitor xenobiotic antiviral drug carboxamide 1,3-thiazole 1,3-thiazoles ritonavir Ritonavir 85762 KEGG:D00427 C37H48N6O5S2 PMID:24202050 KEGG:C07240 PMID:11363184 CHEBI:8873 LINCS:LSM-5623 PMID:11363300 CAS:155213-67-5 PMID:9585800 PMID:11996889 0 PMID:11363329 720.94400 PMID:11363086 CHEBI:45409 CC(C)[C@H](NC(=O)N(C)Cc1csc(n1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)Cc1ccccc1 Drug_Central:2391 PDBeChem:RIT PMID:11363517 HMDB:HMDB0014646 ritonavir PMID: 26198719; PMID: 27344959; PMID: 14985565 PMID:9140265 NCDNCNXCDXHOMX-XGKFQTDJSA-N PMID:11363397 An L-valine derivative that is L-valinamide in which alpha-amino group has been acylated by a [(2-isopropyl-1,3-thiazol-4-yl)methyl]methylcarbamoyl group and in which a hydrogen of the carboxamide amino group has been replaced by a (2R,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl group. A CYP3A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver. Wikipedia:Ritonavir Reaxys:768009 N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N(2)-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide chebi_ontology InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1 720.31276 PMID:8568292 PMID: 27344959; PMID: 15226499; PMID: 16837072 PMID:9278209 ureas environmental contaminant L-valine derivative function-inhibiting cytochrome P450 2D6 (CYP2D6) binding disposition Middle East respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus