chemical inhibits protein chemical has protein target as antagonist chemical inhibits in vitro invasion of virus has role has role has functional parent benzamides pyridines benzamide aromatic amine antineoplastic agent tyrosine kinase inhibitor pyrimidines imatinib CAS:152459-95-5 alpha-(4-methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-toluidide KTUFNOKKBVMGRW-UHFFFAOYSA-N CHEBI:305376 PMID:18809244 PMID:22891806 PMID:14715630 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE STI 571 Patent:US5521184 PMID:19415889 PMID:19591692 Patent:EP564409 C29H31N7O PMID:17457302 PMID:18420270 PMID:16983347 PMID:18376233 PMID:19693287 PMID: 30711575 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) HMDB:HMDB0014757 PMID:19097599 PMID:19527930 PMID:18780518 PMID:23503753 chebi_ontology PMID:18337118 LINCS:LSM-1023 PMID:16826359 PMID:23183914 PMID:18423008 PMID:17717205 https://www.drugbank.ca/drugs/DB00619 0 PMID:19182535 PMID:18623899 PMID:19749465 Beilstein:7671333 CHEBI:45783 PMID:23313020 PMID:23394269 PMID:23587588 PMID:15966213 imatinib DrugBank:DB00619 PDBeChem:STI PMID:23580311 493.25901 PMID:19810774 A benzamide obtained by formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid with the primary aromatic amino group of 4-methyl-N(3)-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine. Used (as its mesylate salt) for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours. Drug_Central:1423 PMID:18193246 PMID:19052981 PMID:18216472 PMID:14660054 PMID:18407734 CHEBI:38918 PMID:19242505 PMID:15073101 PMID:17410337 PMID:19853594 PMID:15170967 PMID:18548219 493.60270 PMID:23536338 PMID:23480638 PMID:15722647 4-[(4-methylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzamide CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 PMID:17190842 Reaxys:7671333 Wikipedia:Imatinib PMID:23075630 KEGG:D08066 PMID:19020005 PMID:23574742 PMID:18344535 PMID:19920908 CHEBI:45781 PMID:15794712 PMID:19077095 PMID:16122278 N-methylpiperazine apoptosis inducer Middle East respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus tyrosine-protein kinase ABL1 (human) high affinity nerve growth factor receptor (human) macrophage colony-stimulating factor 1 receptor (human) platelet-derived growth factor receptor beta (human) mast/stem cell growth factor receptor Kit (human) breakpoint cluster region protein (human) platelet-derived growth factor receptor alpha (human) epithelial discoidin domain-containing receptor 1 (human)