chemical has protein target chemical inhibits protein chemical has protein target as antagonist chemical has protein target as potentiator chemical inhibits in vitro invasion of virus has role has role anticoronaviral agent monocarboxylic acid amide antineoplastic agent organochlorine compound aminopyrimidine 1,3-thiazole 1,3-thiazoles tyrosine kinase inhibitor N-arylpiperazine N-(2-hydroxyethyl)piperazine dasatinib (anhydrous) CHEBI:49375 PMID:19502192 HMDB:HMDB0015384 N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE anhydrous dasatinib PMID:17154512 BMS-354825 PMID:19494352 488.00652 dasatinib CAS:302962-49-8 PMID:22411867 PMID:22992064 PMID:18784745 DrugBank:DB01254 PMID:21226671 0 PDBeChem:1N1 PMID:18797457 ZBNZXTGUTAYRHI-UHFFFAOYSA-N Patent:WO2010139979 anh. dasatinib Patent:US7125875 KEGG:D03658 PMID:18823558 An aminopyrimidine that is 2-methylpyrimidine which is substituted at position 4 by the primary amino group of 2-amino-1,3-thiazole-5-carboxylic acid and at position 6 by a 4-(2-hydroxyethyl)piperazin-1-yl group, and in which the carboxylic acid group has been formally condensed with 2-chloro-6-methylaniline to afford the corresponding amide. A multi-targeted kinase inhibitor, it is used, particularly as the monohydrate, for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN). PMID: 24841273; PMID: 26868298 PMID:18020922 Drug_Central:785 PMID:16775234 CHEBI:38943 BMS Dasatinib https://www.drugbank.ca/drugs/DB01254 PMID:23065516 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 dasatinibum Patent:US7941725 C22H26ClN7O2S PMID:19640584 LINCS:LSM-1020 Reaxys:9966762 chebi_ontology Patent:WO2010067374 N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide PMID:22740998 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) 487.15572 Wikipedia:Dasatinib dasatinib (anh.) CHEBI:49372 secondary amino compound tertiary amino compound Middle East respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus tyrosine-protein kinase ABL1 (human) tyrosine-protein kinase Lck (human) tyrosine-protein kinase Fyn (human) tyrosine-protein kinase Yes (human) tyrosine-protein kinase Lyn (human) platelet-derived growth factor receptor beta (human) tyrosine-protein kinase Fgr (human) mast/stem cell growth factor receptor Kit (human) heat shock cognate 71 kDa protein (human) breakpoint cluster region protein (human) proto-oncogene tyrosine-protein kinase Src (human) ephrin type-A receptor 2 (human) tyrosine-protein kinase CSK (human) tyrosine-protein kinase ABL2 (human) tyrosine-protein kinase FRK (human) signal transducer and activator of transcription 5B (human) ephrin type-A receptor 5 (human) ephrin type-B receptor 4 (human) tyrosine-protein kinase BTK (human) amidophosphoribosyltransferase (human) mitogen-activated protein kinase 14 (human) nuclear receptor subfamily 4 group A member 3 (human) mitogen-activated protein kinase kinase kinase 20 (human)