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    <!-- http://purl.obolibrary.org/obo/RO_0000087 -->

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        <rdfs:label>has role</rdfs:label>
        <rdfs:label xml:lang="en">has role</rdfs:label>
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        <rdfs:label>has functional parent</rdfs:label>
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        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:label>is tautomer of</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_15428 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_15428">
        <rdfs:label>glycine</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_16643 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_16643">
        <rdfs:label>L-methionine</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_17295 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_17295">
        <rdfs:label>L-phenylalanine</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_17895 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_17895">
        <rdfs:label>L-tyrosine</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_189868 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_189868">
        <rdfs:label>Met-enkephalin zwitterion</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35480 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35480">
        <rdfs:label>analgesic</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35610 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35610">
        <rdfs:label>antineoplastic agent</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_48545 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_48545">
        <rdfs:label>pentapeptide</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_55322 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_55322">
        <rdfs:label>mu-opioid receptor agonist</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_64054 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_64054">
        <rdfs:label>delta-opioid receptor agonist</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_6618 -->

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        <rdfs:label>Met-enkephalin</rdfs:label>
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        </rdfs:subClassOf>
        <oboInOwl:hasDbXref>Wikipedia:Met-enkephalin</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>metenkefalin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>metenkefaline</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <ns5:inchi>InChI=1S/C27H35N5O7S/c1-40-12-11-21(27(38)39)32-26(37)22(14-17-5-3-2-4-6-17)31-24(35)16-29-23(34)15-30-25(36)20(28)13-18-7-9-19(33)10-8-18/h2-10,20-22,33H,11-16,28H2,1H3,(H,29,34)(H,30,36)(H,31,35)(H,32,37)(H,38,39)/t20-,21-,22-/m0/s1</ns5:inchi>
        <oboInOwl:hasRelatedSynonym>opioid growth factor (OGF)</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:30422494</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>MET-enkephalin</oboInOwl:hasExactSynonym>
        <oboInOwl:hasRelatedSynonym>[Met(5)]-enkephalin</oboInOwl:hasRelatedSynonym>
        <ns5:inchikey>YFGBQHOOROIVKG-FKBYEOEOSA-N</ns5:inchikey>
        <ns5:formula>C27H35N5O7S</ns5:formula>
        <ns3:IAO_0000115>A pentapeptide comprising L-tyrosine, glycine, glycine, L-phenylalanine and L-methionine residues joined in sequence by peptide linkages. It is an endogenous opioid peptide with antitumor, analgesic, and immune-boosting properties.</ns3:IAO_0000115>
        <oboInOwl:id>CHEBI:6618</oboInOwl:id>
        <oboInOwl:hasDbXref>PMID:31835089</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:34315116</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>CAS:58569-55-4</oboInOwl:hasDbXref>
        <ns5:mass>573.670</ns5:mass>
        <oboInOwl:hasDbXref>Chemspider:391597</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>Tyr-Gly-Gly-Phe-Met</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>Tyr-Gly-Gly-Phe-Met-OH</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>enkephalin, methionine</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:32412087</oboInOwl:hasDbXref>
        <ns5:charge>0</ns5:charge>
        <oboInOwl:hasDbXref>PMID:30930116</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>L-Tyr-Gly-Gly-L-Phe-L-Met</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:31994797</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:34426103</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>metencefalina</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>H-L-Tyr-Gly-Gly-L-Phe-L-Met-OH</oboInOwl:hasRelatedSynonym>
        <ns5:smiles>CSCCC(NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)C(N)CC1=CC=C(O)C=C1)C(O)=O</ns5:smiles>
        <oboInOwl:hasDbXref>PMID:34116288</oboInOwl:hasDbXref>
        <ns5:monoisotopicmass>573.22572</ns5:monoisotopicmass>
        <oboInOwl:hasDbXref>PMID:33957231</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>MENK</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:31078923</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:32129162</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:32535097</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>DrugBank:DB12668</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>[Met(5)]enkephalin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasExactSynonym>L-tyrosylglycylglycyl-L-phenylalanyl-L-methionine</oboInOwl:hasExactSynonym>
        <oboInOwl:hasRelatedSynonym>Lupex</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>methionine enkephalin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>opioid growth factor</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:32491696</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>metenkefalinum</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:33965882</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:32666020</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:31404891</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>methionine-enkephalin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:34324868</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:34309826</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:34311187</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>KEGG:C11684</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:33620466</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>M-ENK</oboInOwl:hasRelatedSynonym>
        <oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR"/>
        <ns3:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/chebi.owl"/>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_77746 -->

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        <rdfs:label>human metabolite</rdfs:label>
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