chemical inhibits in vitro replication of virus has role has role quinolone monocarboxylic acid amide phenols aromatic amide ivacaftor PMID:22499233 Kalydeco ivacaftorum PMID:22383668 PMID:22293084 KEGG:D09916 PMID:22723294 An aromatic amide obtained by formal condensation of the carboxy group of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid with the amino group of 5-amino-2,4-di-tert-butylphenol. Used for the treatment of cystic fibrosis. chebi_ontology PMID:22047557 PMID:22739718 Wikipedia:Ivacaftor CAS:873054-44-5 PMID:22543461 392.20999 VX-770 0 InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29) PURKAOJPTOLRMP-UHFFFAOYSA-N 392.49070 N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide PMID:22618984 PMID:22508750 CC(C)(C)c1cc(c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O)C(C)(C)C ivacaftor PMID:22768130 CHEBI:66901 Reaxys:11821038 PMID: 32366720 Drug_Central:4228 C24H28N2O3 PMID:22698459 CFTR potentiator orphan drug Severe acute respiratory syndrome-related coronavirus