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    <!-- http://purl.obolibrary.org/obo/CIDO_0000119 -->

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        <rdfs:label xml:lang="en">chemical inhibits protein</rdfs:label>
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        <rdfs:label>has role</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_176497 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_176497">
        <rdfs:label>geroprotector</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_24436 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_24436">
        <rdfs:label>guanidines</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_3095 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_3095">
        <rdfs:label>biguanide</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_35222 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35222">
        <rdfs:label>inhibitor</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_35526 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35526">
        <rdfs:label>hypoglycemic agent</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_35703 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35703">
        <rdfs:label>xenobiotic</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_6801 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_6801">
        <rdfs:label>metformin</rdfs:label>
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        <oboInOwl:hasDbXref>PMID:15606381</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:10983737</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>N(1),N(1)-dimethylbiguanide</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>KEGG:C07151</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:18608522</oboInOwl:hasDbXref>
        <ns5:inchi>InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)</ns5:inchi>
        <oboInOwl:hasDbXref>PMID:16520442</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>N,N-dimethylguanylguanidine</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:12436333</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:11544610</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:12086935</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>LA 6023</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasExactSynonym>N,N-dimethyltriimidodicarbonic diamide</oboInOwl:hasExactSynonym>
        <oboInOwl:hasRelatedSynonym>dimethyldiguanide</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>Wikipedia:Metformin</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:15717887</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>DrugBank:DB00331</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:11257323</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:10900588</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:31208831</oboInOwl:hasDbXref>
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        <oboInOwl:hasDbXref>PMID:12630933</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:12406042</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>CAS:657-24-9</oboInOwl:hasDbXref>
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        <oboInOwl:hasDbXref>PDBeChem:MF8</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HMDB:HMDB0001921</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>metformine</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:15932841</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:11192132</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>metformina</oboInOwl:hasRelatedSynonym>
        <ns5:monoisotopicmass>129.10145</ns5:monoisotopicmass>
        <oboInOwl:hasDbXref>PMID:10999803</oboInOwl:hasDbXref>
        <ns3:IAO_0000115>A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.</ns3:IAO_0000115>
        <oboInOwl:hasDbXref>PMID:18212742</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>N,N-dimethylbiguanide</oboInOwl:hasRelatedSynonym>
        <ns5:mass>129.167</ns5:mass>
        <oboInOwl:hasDbXref>FooDB:FDB022739</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>N,N-dimethyldiguanide</oboInOwl:hasRelatedSynonym>
        <ns5:formula>C4H11N5</ns5:formula>
        <oboInOwl:hasDbXref>PMID:16294070</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:11772907</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>LA-6023</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:11126815</oboInOwl:hasDbXref>
        <ns5:charge>0</ns5:charge>
        <oboInOwl:hasDbXref>Drug_Central:1725</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>N,N-dimethylimidodicarbonimidic diamide</oboInOwl:hasRelatedSynonym>
        <ns5:inchikey>XZWYZXLIPXDOLR-UHFFFAOYSA-N</ns5:inchikey>
        <oboInOwl:hasDbXref>PMID:23077661</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:15650645</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:17062558</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:28919040</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>metforminum</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>KEGG:D04966</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Reaxys:606492</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>LINCS:LSM-4730</oboInOwl:hasDbXref>
        <ns3:IAO_0000119>Reference: PMID: 24843020</ns3:IAO_0000119>
        <oboInOwl:hasDbXref>PMID:11012555</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>dimethylbiguanide</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:12909816</oboInOwl:hasDbXref>
        <oboInOwl:id>CHEBI:6801</oboInOwl:id>
        <oboInOwl:hasDbXref>PMID:15261814</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:16941277</oboInOwl:hasDbXref>
        <ns5:smiles>CN(C)C(=N)NC(N)=N</ns5:smiles>
        <oboInOwl:hasDbXref>PMID:33191721</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>1,1-dimethylbiguanide</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>metformin</oboInOwl:hasRelatedSynonym>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_78298 -->

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        <rdfs:label>environmental contaminant</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/CHEBI_90688 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_90688">
        <rdfs:label>metformin(1+)</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/PR_000011096 -->

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        <rdfs:label>NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial</rdfs:label>
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