chemical inhibits protein chemical inhibits in vitro replication of virus has role has role has functional parent macrolide lactam anticoronaviral agent primary alcohol geroprotector ether antineoplastic agent secondary alcohol immunosuppressive agent cyclic ketone cyclic acetal everolimus HMDB:HMDB0015529 Patent:RU2008143550 0 Wikipedia:Everolimus PMID:34527569 Patent:CN102138903 PMID:34225066 PMID:33998365 PMID:34299359 PMID:22967800 (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,35R)-1,18-dihydroxy-12-{(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0(4,9)]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone everolimusum https://www.drugbank.ca/drugs/DB01590 chebi_ontology Votubia PMID:22969095 Chemspider:21106307 PMID:33640871 SDZ RAD A macrocyclic lactone that is rapamycin in which the hydroxy group attached to the cyclohexyl moiety has been converted into the corresponding 2-hydroxyethyl ether. It is an immunosuppressant and antineoplastic agent. everolimus PMID:31478889 PMID:22683823 PMID:34242751 CHEBI:68478 PMID:22404500 42-O-(2-hydroxyethyl)rapamycin PMID: 26868298 KEGG:D02714 40-O-(2-hydroxyethyl)-rapamycin Drug_Central:1118 Certican PMID:34467233 C53H83NO14 InChI=1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1 HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus PMID:22983698 Afinitor Disperz PMID:34491881 RAD001 Patent:WO2012066502 LINCS:LSM-43172 PMID:34253597 PMID:22363408 RAD 001 [H][C@]1(CC[C@@H](OCCO)[C@@H](C1)OC)C[C@@H](C)[C@]1([H])CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@]2([H])CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@@]2([H])C(=O)O1)OC PMID:22461124 CAS:159351-69-6 Xience V Afinitor Zortress PMID:33986025 (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone PMID:34018490 957.58136 958.22440 DrugBank:DB01590 PMID:22986894 SDZ-RAD mTOR inhibitor sirolimus Middle East respiratory syndrome-related coronavirus serine/threonine-protein kinase mTOR (human)