has role has role anticoronaviral agent geroprotector acetamides aromatic amine antineoplastic agent ring assembly organoiodine compound organofluorine compound pyridopyrimidine cyclopropanes trametinib PMID:34145930 PMID:21523318 PMID:23290787 JTP 74057 Patent:WO2011038082 trametinib PMID:23807941 CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O PMID:23432625 C26H23FIN5O4 PMID:23533766 PMID:22245957 Wikipedia:Trametinib KEGG:D10175 PMID:23035153 PMID:23709751 PMID:24055054 Reaxys:12497153 PMID:33922284 PMID:23441129 chebi_ontology PMCID:PMC7715110 Chemspider:9881833 InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34) PMID:34282746 Drug_Central:4802 PMID:34421360 PMID:23649971 PMID:23248257 PMID:23893461 PMID:23977666 GSK 1120212 A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment. PMID:23583440 trametinibum PMID:34355652 PMID:34034619 615.39480 PMID:23658559 CAS:871700-17-3 LINCS:LSM-1143 Patent:WO2011047238 PMID:23971497 LIRYPHYGHXZJBZ-UHFFFAOYSA-N PMID:34516041 PMID:23587417 PMID:23237773 PMID:34592184 PMID:34156985 Patent:WO2005121142 DrugBank:DB08911 PMID:34413035 CHEBI:75998 0 N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide Patent:WO2011038085 PMID:34484797 615.07788 PMID:26119340 PMID:23844038 PMID:23438367 PMID:23846731 PMID:34590600 EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor