chemical inhibits protein has role has role benzamides inhibitor antineoplastic agent tyrosine kinase inhibitor N-methylpiperazine imidazopyridazine acetylenic compound ponatinib PMID:24408322 Patent:US2014038920 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide AP24534 PMID:24768818 PMID:24552773 PMID:24550512 PMID:24472312 C29H27F3N6O PMID:24481648 Wikipedia:Ponatinib Reference: PMID: 25801024 ponatinibum PMID:24407160 PMID:24934866 PMID:24596204 CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1 chebi_ontology 532.55950 Drug_Central:4716 PMID:24586514 Reaxys:12923700 LINCS:LSM-1151 InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39) PMID:24766374 PMID:24297701 PMID:24756787 PMID:24402926 A benzamide obtained by the formal condensation of the carboxy group of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid with the anilino group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline. PMID:24807266 0 KEGG:D09950 AP 24534 PMID:24602068 CAS:943319-70-8 CHEBI:78543 532.21984 PHXJVRSECIGDHY-UHFFFAOYSA-N ponatinib PMID:24695735 PMID:24729118 (trifluoromethyl)benzenes receptor-interacting serine/threonine-protein kinase 1