<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/CIDO?iri=http://purl.obolibrary.org/obo/CHEBI_80128"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:ns5="http://purl.obolibrary.org/obo/chebi/"
     xmlns:chebi="http://purl.obolibrary.org/obo/chebi#"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/"
     xmlns:ns3="http://purl.obolibrary.org/obo/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000412"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/inchi"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/charge"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/smiles"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBONamespace"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/inchikey"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/monoisotopicmass"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/formula"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/mass"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/RO_0000087 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000087">
        <rdfs:label>has role</rdfs:label>
        <rdfs:label xml:lang="en">has role</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/chebi#is_tautomer_of -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/chebi#is_tautomer_of">
        <rdf:type rdf:resource="http://www.w3.org/2002/07/owl#TransitiveProperty"/>
        <rdfs:label>is tautomer of</rdfs:label>
    </ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/CHEBI_147351 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_147351">
        <rdfs:label>angiotensin (1-9) dizwitterion</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35674 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35674">
        <rdfs:label>antihypertensive agent</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_48433 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_48433">
        <rdfs:label>angiotensin</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_77307 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_77307">
        <rdfs:label>cardioprotective agent</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_77746 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_77746">
        <rdfs:label>human metabolite</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_80128 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_80128">
        <rdfs:label>angiotensin (1-9)</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_48433"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_tautomer_of"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_147351"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_86264"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35674"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77307"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_77746"/>
            </Restriction>
        </rdfs:subClassOf>
        <oboInOwl:hasDbXref>PMID:24593683</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:30048754</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:24177599</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:24991796</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:20411619</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:24991795</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>[des-Leu(10)]-angiotensin I</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:32152556</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>D-R-V-Y-I-H-P-F-H</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:26238180</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:27978951</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:27978950</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>angiotensin I (1-9)</oboInOwl:hasRelatedSynonym>
        <ns5:inchi>InChI=1S/C56H78N16O13/c1-5-31(4)46(71-50(79)40(22-33-15-17-36(73)18-16-33)67-52(81)45(30(2)3)70-48(77)38(13-9-19-62-56(58)59)65-47(76)37(57)25-44(74)75)53(82)68-41(23-34-26-60-28-63-34)54(83)72-20-10-14-43(72)51(80)66-39(21-32-11-7-6-8-12-32)49(78)69-42(55(84)85)24-35-27-61-29-64-35/h6-8,11-12,15-18,26-31,37-43,45-46,73H,5,9-10,13-14,19-25,57H2,1-4H3,(H,60,63)(H,61,64)(H,65,76)(H,66,80)(H,67,81)(H,68,82)(H,69,78)(H,70,77)(H,71,79)(H,74,75)(H,84,85)(H4,58,59,62)/t31-,37-,38-,39-,40-,41-,42-,43-,45-,46-/m0/s1</ns5:inchi>
        <oboInOwl:hasDbXref>PMID:10969042</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:25801006</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:22184331</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>angiotensin-(1-9)</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:2780412</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>KEGG:C15851</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:23884911</oboInOwl:hasDbXref>
        <ns5:inchikey>LJXGOQOPNPFXFT-JWRYNVNRSA-N</ns5:inchikey>
        <oboInOwl:hasRelatedSynonym>des-Leu angiotensin I</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>ang-(1-9)</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>DRVYIHPFH</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:15283675</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:30179588</oboInOwl:hasDbXref>
        <ns5:formula>C56H78N16O13</ns5:formula>
        <oboInOwl:hasDbXref>PMID:26988149</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:23029101</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:29962859</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:id>CHEBI:80128</oboInOwl:id>
        <oboInOwl:hasRelatedSynonym>L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro-L-Phe-L-His</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:25029123</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:31563322</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:2170511</oboInOwl:hasDbXref>
        <ns5:smiles>[C@H](NC([C@H](CC(O)=O)N)=O)(CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@@H](CCC1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CNC=N3)C(O)=O)=O)=O)=O)CC4=CN=CN4)=O)[C@H](CC)C)=O)CC=5C=CC(=CC5)O)=O)C(C)C)=O</ns5:smiles>
        <ns5:mass>1183.339</ns5:mass>
        <ns5:charge>0</ns5:charge>
        <ns3:IAO_0000115>A nine amino acid peptide which is formed when angiotensin converting enzyme 2 (ACE2) hydrolyzes the carboxy terminal leucine from angiotensin I. It is a anti-cardiac hypertrophy agent.</ns3:IAO_0000115>
        <oboInOwl:hasDbXref>PMID:20610862</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:24463937</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:19790042</oboInOwl:hasDbXref>
        <ns5:monoisotopicmass>1182.59343</ns5:monoisotopicmass>
        <oboInOwl:hasDbXref>CAS:34273-12-6</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:21330937</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidine</oboInOwl:hasExactSynonym>
        <oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR"/>
        <ns3:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/chebi.owl"/>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_86264 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_86264">
        <rdfs:label>rat metabolite</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



