chemical inhibits protein chemical inhibits in vitro replication of virus has role has role anticoronaviral agent benzimidazoles antineoplastic agent organofluorine compound bromobenzenes secondary amino compound hydroxamic acid ester EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor monochlorobenzenes selumetinib A member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-chlorophenyl)amino, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor. PMID:22241789 PMID:20978926 PMID:22343622 0 selumetinibum LINCS:LSM-1056 AZD6244 PMID:26384399 PMID:21594619 C17H15BrClFN4O3 CYOHGALHFOKKQC-UHFFFAOYSA-N PMID:22565394 PMID: 26868298 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide Wikipedia:Selumetinib chebi_ontology PMID:25379021 AZD-6244 PMID:25637165 PMID:25498501 PMID:25342139 N1(C=NC2=C1C=C(C(=C2F)NC3=CC=C(C=C3Cl)Br)C(=O)NOCCO)C CAS:606143-52-6 456.00001 InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26) PMID:20407895 PMID:25887099 PMID:23444215 https://www.drugbank.ca/drugs/DB11689 ARRY-142886 457.682 ARRY142886 AZD 6244 PMID:23372439 PMID:22972589 PDBeChem:3EW PMID:26059332 PMID:23942066 PMID:25385055 PMID:26446942 CHEBI:90227 Reaxys:11099648 PMID:25322874 KEGG:D09666 selumetinib ARRY 142886 PMID:22394161 Middle East respiratory syndrome-related coronavirus dual specificity mitogen-activated protein kinase kinase 2 (human) dual specificity mitogen-activated protein kinase kinase 1 (human)