<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/CIDO?iri=http://purl.obolibrary.org/obo/CHEBI_90705"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:ns5="http://purl.obolibrary.org/obo/chebi/"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/"
     xmlns:ns3="http://purl.obolibrary.org/obo/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000119"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000412"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/inchi"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/charge"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/smiles"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBONamespace"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/inchikey"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/monoisotopicmass"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/formula"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/mass"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/CIDO_0000144 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/CIDO_0000144">
        <rdfs:label xml:lang="en">chemical inhibits in vitro replication of virus</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0000087 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000087">
        <rdfs:label>has role</rdfs:label>
        <rdfs:label xml:lang="en">has role</rdfs:label>
    </ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/CHEBI_176497 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_176497">
        <rdfs:label>geroprotector</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_22063 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_22063">
        <rdfs:label>sulfoxide</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_24780 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_24780">
        <rdfs:label>imidazoles</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_26421 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_26421">
        <rdfs:label>pyridines</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_50925 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_50925">
        <rdfs:label>EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_63726 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_63726">
        <rdfs:label>neuroprotective agent</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_63962 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_63962">
        <rdfs:label>Hsp90 inhibitor</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_79091 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_79091">
        <rdfs:label>EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_83575 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_83575">
        <rdfs:label>monofluorobenzenes</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_90705 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_90705">
        <rdfs:label>SB 203580</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_22063"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24780"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26421"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_83575"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_79091"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_63726"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/CIDO_0000144"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_694009"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_63962"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/CIDO_0000144"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_1335626"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_176497"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50925"/>
            </Restriction>
        </rdfs:subClassOf>
        <oboInOwl:hasDbXref>PMID:25465717</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>CAS:152121-47-6</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:26423029</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:11889071</oboInOwl:hasDbXref>
        <ns3:IAO_0000115>A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.</ns3:IAO_0000115>
        <oboInOwl:hasDbXref>PMID:25593217</oboInOwl:hasDbXref>
        <ns5:charge>0</ns5:charge>
        <oboInOwl:hasDbXref>PMID:30094758</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>SB203580</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasExactSynonym>4-{4-(4-fluorophenyl)-2-[4-(methanesulfinyl)phenyl]-1H-imidazol-5-yl}pyridine</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>PMID:25724654</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:25744405</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:31410128</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:26537343</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:26350014</oboInOwl:hasDbXref>
        <ns5:formula>C21H16FN3OS</ns5:formula>
        <oboInOwl:hasDbXref>HMDB:HMDB0244686</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:22363408</oboInOwl:hasDbXref>
        <ns3:IAO_0000119>PMID: 24699705; PMID: 27344959</ns3:IAO_0000119>
        <ns5:inchikey>CDMGBJANTYXAIV-UHFFFAOYSA-N</ns5:inchikey>
        <oboInOwl:hasDbXref>PMID:25172309</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:11457647</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:32626961</oboInOwl:hasDbXref>
        <ns5:inchi>InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)</ns5:inchi>
        <ns5:smiles>S(C=1C=CC(C2=NC(C=3C=CN=CC3)=C(N2)C4=CC=C(C=C4)F)=CC1)(C)=O</ns5:smiles>
        <oboInOwl:hasDbXref>PMID:9786874</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>SB-203580</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:25676262</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:31645486</oboInOwl:hasDbXref>
        <oboInOwl:id>CHEBI:90705</oboInOwl:id>
        <oboInOwl:hasDbXref>Wikipedia:SB_203580</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Reaxys:8078222</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:25727011</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:25500336</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:19336000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:25242011</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:hasDbXref>PMID:25655298</oboInOwl:hasDbXref>
        <ns5:mass>377.437</ns5:mass>
        <oboInOwl:hasDbXref>PMID:25366607</oboInOwl:hasDbXref>
        <ns5:monoisotopicmass>377.09981</ns5:monoisotopicmass>
        <oboInOwl:hasDbXref>PMID:25924425</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:24563432</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:26277520</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>LINCS:LSM-1168</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:15695561</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:11192367</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:25496832</oboInOwl:hasDbXref>
        <oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR"/>
        <ns3:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/chebi.owl"/>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_1335626 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_1335626">
        <rdfs:label>Middle East respiratory syndrome-related coronavirus</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/NCBITaxon_694009 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/NCBITaxon_694009">
        <rdfs:label>Severe acute respiratory syndrome-related coronavirus</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



