has role has role nitrile antiviral agent pyrazoles sulfonamide immunosuppressive agent antirheumatic drug pyrrolopyrimidine azetidines anti-inflammatory agent EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor baricitinib PMID:34110416 PMID:34358107 PMID:34747511 baricitinib PMID:30036348 PMID:33870531 A pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted by a 1-[3-(cyanomethyl)-1-(ethanesulfonyl)azetidin-3-yl]-1H-pyrazol-4-yl group at position 5. It is an FDA approved selective Janus Kinase 1 and 2 (JAK1 and JAK2) inhibitor used for the treatment of rheumatoid arthritis. DrugBank:DB11817 PMID:34647989 LINCS:LSM-6709 Chemspider:26373084 371.420 PMID:34379541 PMID:34250455 371.11644 PMID:33456084 PMID:34468689 baricitinibum Wikipedia:Baricitinib HMDB:HMDB0248873 INCB028050 PMID:27910962 C16H17N7O2S PMID:34237007 chebi_ontology PMID:30907116 CHEBI:95341 PMID:34785883 INCB-028050 KEGG:D10308 PMID:34424311 INCB 028050 PDBeChem:3JW XUZMWHLSFXCVMG-UHFFFAOYSA-N LY3009104 PMID:26853940 LY-3009104 1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile PMID:34553429 PMID:33961266 PMID:34501467 PMID:32856090 2-(3-(4-(3H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile PMID:33451175 CAS:1187594-09-7 PMID:30871014 PMID:34393789 Olumiant InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20) 0 PMID:34195587 PMID:33502499 CCS(=O)(=O)N1CC(CC#N)(C1)N1C=C(C=N1)C1=C2C=CNC2=NC=N1 {1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile PMID:34321249 LY 3009104 PMCID:PMC8606629 PMID:34247230