molecularly interacts with nsp5_C145A A catalytically dead Nsp5 (C145A) with tRNA methyltransferase 1 (TRMT1), which is responsible for the dimethylation of guanosine (m2,2G) on both nuclear and mitochondrial tRNAs (Ref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431030/). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431030/ Anthony Huffman, Oliver He 3C-like proteinase (SARS-CoV-2) 3C-like proteinase nsp5 (SARS-CoV-2) glutathione peroxidase 1 (human) tRNA (guanine(26)-N(2))-dimethyltransferase (human)