biochemical role lysosomotropic agent role A role taked by an agent that can induce lysosomotropism. Weak bases with lipophilic properties accumulate in acidic intracellular compartments like lysosomes. While the plasma and lysosomal membranes are permeable for neutral and uncharged species of weak bases, the charged protonated species of weak bases do not permeate biomembranes and accumulate within lysosomes. The concentration within lysosomes may reach levels 100 to 1000 fold higher than extracellular concentrations. This phenomenon is called lysosomotropism, "acid trapping" or "proton pump" effect. Oliver He, Yingtong Liu https://en.wikipedia.org/wiki/Lysosome#Lysosomotropism