chemical inhibits protein chemical has protein target as agonist molecular entity Fostamatinib Zalan Shah, Ashley Yan https://go.drugbank.com/drugs/DB12010 bone morphogenetic protein receptor type-1B (human) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (human) serine/threonine-protein kinase PLK4 (human) fatty-acid amide hydrolase 1 (human) phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (human) citron Rho-interacting kinase (human) serine/threonine-protein kinase RIO3 (human) serine/threonine-protein kinase Chk1 (human) inhibitor of nuclear factor kappa-B kinase subunit beta (human) peripheral plasma membrane protein CASK (human) aurora kinase A (human) cyclin-G-associated kinase (human) serine/threonine-protein kinase DCLK1 (human) muscle, skeletal receptor tyrosine-protein kinase (human) ephrin type-B receptor 6 (human) mitogen-activated protein kinase 13 (human) 3-phosphoinositide-dependent protein kinase 1 (human) mitogen-activated protein kinase kinase kinase 13 (human) death-associated protein kinase 3 (human) receptor-interacting serine/threonine-protein kinase 2 (human) NUAK family SNF1-like kinase 1 (human) tyrosine-protein kinase JAK2 (human) Rho-associated protein kinase 2 (human) serine/threonine-protein kinase ULK1 (human) serine/threonine-protein kinase/endoribonuclease IRE1 (human) serine/threonine-protein kinase 16 (human) phosphatidylinositol 3-kinase C2 domain-containing subunit gamma (human) serine/threonine-protein kinase PAK 3 (human) cGMP-specific 3',5'-cyclic phosphodiesterase (human) serine/threonine-protein kinase 17B (human) serine/threonine-protein kinase 10 (human) mitogen-activated protein kinase kinase kinase 6 (human) serine/threonine-protein kinase OSR1 (human) mitogen-activated protein kinase kinase kinase kinase 4 (human) serine/threonine-protein kinase LATS1 (human) serine/threonine-protein kinase PAK 4 (human) serine/threonine-protein kinase Chk2 (human) tyrosine-protein kinase ABL1 (human) epidermal growth factor receptor (human) RAF proto-oncogene serine/threonine-protein kinase (human) receptor tyrosine-protein kinase erbB-2 (human) high affinity nerve growth factor receptor (human) protein kinase C gamma type (human) insulin receptor (human) tyrosine-protein kinase Lck (human) tyrosine-protein kinase Fyn (human) cyclin-dependent kinase 1 (human) tyrosine-protein kinase Fes/Fps (human) macrophage colony-stimulating factor 1 receptor (human) kappa-casein (human) procathepsin L (human) tyrosine-protein kinase Yes (human) tyrosine-protein kinase Lyn (human) proto-oncogene tyrosine-protein kinase receptor Ret (human) hepatocyte growth factor receptor (human) tyrosine-protein kinase HCK (human) proto-oncogene tyrosine-protein kinase ROS (human) platelet-derived growth factor receptor beta (human) tyrosine-protein kinase Fgr (human) polyunsaturated fatty acid 5-lipoxygenase (human) uncharacterized serine/threonine-protein kinase SBK3 (human) adenosine receptor A3 (human) mast/stem cell growth factor receptor Kit (human) serine/threonine-protein kinase pim-1 (human) fibroblast growth factor receptor 1 (human) cyclin-dependent kinase 4 (human) proto-oncogene tyrosine-protein kinase Src (human) insulin receptor-related protein (human) serine/threonine-protein kinase B-raf (human) platelet-derived growth factor receptor alpha (human) tyrosine-protein kinase Fer (human) cAMP-dependent protein kinase catalytic subunit alpha (human) vascular endothelial growth factor receptor 1 (human) interferon-induced, double-stranded RNA-activated protein kinase (human) casein kinase II subunit alpha' (human) ephrin type-A receptor 1 (human) fibroblast growth factor receptor 2 (human) UDP-glucuronosyltransferase 1A1 (human) fibroblast growth factor receptor 3 (human) cAMP-dependent protein kinase catalytic subunit beta (human) tyrosine-protein kinase JAK1 (human) cathepsin S (human) MAP/microtubule affinity-regulating kinase 3 (human) ephrin type-A receptor 2 (human) ephrin type-A receptor 3 (human) ephrin type-A receptor 8 (human) ephrin type-B receptor 2 (human) leukocyte tyrosine kinase receptor (human) non-receptor tyrosine-protein kinase TYK2 (human) Wee1-like protein kinase (human) tyrosine-protein kinase receptor UFO (human) mitogen-activated protein kinase 4 (human) dual specificity protein kinase TTK (human) tyrosine-protein kinase receptor Tie-1 (human) vascular endothelial growth factor receptor 3 (human) vascular endothelial growth factor receptor 2 (human) dual specificity mitogen-activated protein kinase kinase 2 (human) receptor-type tyrosine-protein kinase FLT3 (human) activin receptor type-1B (human) TGF-beta receptor type-1 (human) TGF-beta receptor type-2 (human) tyrosine-protein kinase CSK (human) protein kinase C iota type (human) serine/threonine-protein kinase mTOR (human) megakaryocyte-associated tyrosine-protein kinase (human) tyrosine-protein kinase Tec (human) tyrosine-protein kinase TXK (human) tyrosine-protein kinase ABL2 (human) tyrosine-protein kinase FRK (human) tyrosine-protein kinase ZAP-70 (human) tyrosine-protein kinase SYK (human) mitogen-activated protein kinase 9 (human) dual specificity mitogen-activated protein kinase kinase 3 (human) casein kinase I isoform alpha (human) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (human) dual specificity protein kinase CLK1 (human) dual specificity protein kinase CLK2 (human) dual specificity protein kinase CLK3 (human) glycogen synthase kinase-3 alpha (human) glycogen synthase kinase-3 beta (human) tyrosine-protein kinase Blk (human) interleukin-1 receptor-associated kinase 1 (human) ribosomal protein S6 kinase alpha-3 (human) cytoplasmic tyrosine-protein kinase BMX (human) serine/threonine-protein kinase Nek2 (human) serine/threonine-protein kinase Nek3 (human) serine/threonine-protein kinase Nek4 (human) tyrosine-protein kinase JAK3 (human) dual specificity mitogen-activated protein kinase kinase 6 (human) serine/threonine-protein kinase PLK1 (human) death-associated protein kinase 1 (human) LIM domain kinase 1 (human) LIM domain kinase 2 (human) mitogen-activated protein kinase 10 (human) ephrin type-A receptor 5 (human) ephrin type-B receptor 4 (human) ephrin type-B receptor 1 (human) ephrin type-A receptor 4 (human) serine/threonine-protein kinase SIK1 (human) receptor-interacting serine/threonine-protein kinase 4 (human) casein kinase II subunit alpha (human) phosphatidylinositol 5-phosphate 4-kinase type-2 beta (human) mitogen-activated protein kinase kinase kinase 9 (human) cyclin-dependent kinase-like 1 (human) cyclin-dependent kinase 16 (human) cyclin-dependent kinase 17 (human) protein kinase C epsilon type (human) angiopoietin-1 receptor (human) mitogen-activated protein kinase kinase kinase 10 (human) protein kinase C theta type (human) activin receptor type-1 (human) macrophage-stimulating protein receptor (human) focal adhesion kinase 1 (human) protein kinase C delta type (human) tyrosine-protein kinase BTK (human) tyrosine-protein kinase receptor TYRO3 (human) activated CDC42 kinase 1 (human) epithelial discoidin domain-containing receptor 1 (human) tyrosine-protein kinase ITK/TSK (human) mitogen-activated protein kinase kinase kinase kinase 2 (human) mitogen-activated protein kinase kinase kinase 12 (human) tyrosine-protein kinase Mer (human) 5'-AMP-activated protein kinase catalytic subunit alpha-1 (human) serine/threonine-protein kinase PAK 1 (human) dual specificity mitogen-activated protein kinase kinase 5 (human) mitogen-activated protein kinase 7 (human) serine/threonine-protein kinase PAK 2 (human) serine/threonine-protein kinase 3 (human) mitogen-activated protein kinase kinase kinase 1 (human) cGMP-dependent protein kinase 2 (human) non-receptor tyrosine-protein kinase TNK1 (human) serine/threonine-protein kinase PRP4 homolog (human) receptor-interacting serine/threonine-protein kinase 1 (human) calcium/calmodulin-dependent protein kinase type II subunit beta (human) calcium/calmodulin-dependent protein kinase type II subunit gamma (human) calcium/calmodulin-dependent protein kinase type II subunit delta (human) dual specificity tyrosine-phosphorylation-regulated kinase 1A (human) bone morphogenetic protein receptor type-2 (human) protein-tyrosine kinase 6 (human) calcium/calmodulin-dependent protein kinase type 1 (human) inhibitor of nuclear factor kappa-B kinase subunit epsilon (human) protein-tyrosine kinase 2-beta (human) maternal embryonic leucine zipper kinase (human) serine/threonine-protein kinase D1 (human) serine/threonine-protein kinase 38 (human) receptor tyrosine-protein kinase erbB-4 (human) ephrin type-A receptor 7 (human) ribosomal protein S6 kinase alpha-1 (human) dual specificity testis-specific protein kinase 1 (human) myosin light chain kinase, smooth muscle (human) NT-3 growth factor receptor (human) serine/threonine-protein kinase N1 (human) serine/threonine-protein kinase N2 (human) mitogen-activated protein kinase 14 (human) mitogen-activated protein kinase kinase kinase 11 (human) BDNF/NT-3 growth factors receptor (human) phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (human) discoidin domain-containing receptor 2 (human) AP2-associated protein kinase 1 (human) myosin light chain kinase 3 (human) serine/threonine-protein kinase SBK1 (human) mitogen-activated protein kinase kinase kinase 19 (human) serine/threonine-protein kinase TNNI3K (human) leucine-rich repeat serine/threonine-protein kinase 2 (human) serine/threonine-protein kinase MRCK gamma (human) serine/threonine-protein kinase Nek5 (human) serine/threonine-protein kinase ULK3 (human) mitogen-activated protein kinase kinase kinase 15 (human) serine/threonine-protein kinase MARK2 (human) serine/threonine-protein kinase TAO1 (human) CLIP-associating protein 1 (human) serine/threonine-protein kinase tousled-like 2 (human) serine/threonine-protein kinase pim-3 (human) myosin light chain kinase family member 4 (human) calcium/calmodulin-dependent protein kinase type 1D (human) mitogen-activated protein kinase kinase kinase kinase 3 (human) MAP kinase-activated protein kinase 5 (human) serine/threonine-protein kinase NIM1 (human) serine/threonine-protein kinase ULK2 (human) misshapen-like kinase 1 (human) serine/threonine-protein kinase DCLK2 (human) calcium/calmodulin-dependent protein kinase kinase 1 (human) myosin-IIIa (human) ankyrin repeat and protein kinase domain-containing protein 1 (human) serine/threonine-protein kinase Nek11 (human) atypical kinase COQ8A, mitochondrial (human) phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (human) mitogen-activated protein kinase 15 (human) serine/threonine-protein kinase Nek9 (human) serine/threonine-protein kinase 35 (human) serine/threonine-protein kinase 32A (human) cyclin-dependent kinase-like 2 (human) mitogen-activated protein kinase kinase kinase kinase 1 (human) serine/threonine-protein kinase Sgk3 (human) atypical kinase COQ8B, mitochondrial (human) aurora kinase B (human) MAP/microtubule affinity-regulating kinase 4 (human) calcium/calmodulin-dependent protein kinase type 1G (human) serine/threonine-protein kinase Nek1 (human) cyclin-dependent kinase 15 (human) calcium/calmodulin-dependent protein kinase kinase 2 (human) membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (human) mitogen-activated protein kinase kinase kinase 3 (human) equilibrative nucleoside transporter 1 (human) eukaryotic translation initiation factor 2-alpha kinase 1 (human) serine/threonine-protein kinase RIO1 (human) MAP kinase-interacting serine/threonine-protein kinase 1 (human) serine/threonine-protein kinase RIO2 (human) testis-specific serine/threonine-protein kinase 1 (human) serine/threonine-protein kinase 33 (human) serine/threonine-protein kinase DCLK3 (human) NUAK family SNF1-like kinase 2 (human) serine/threonine-protein kinase SIK2 (human) myosin light chain kinase 2, skeletal/cardiac muscle (human) STE20-like serine/threonine-protein kinase (human) serine/threonine-protein kinase TAO3 (human) homeodomain-interacting protein kinase 2 (human) tyrosine-protein kinase Srms (human) homeodomain-interacting protein kinase 3 (human) serine/threonine-protein kinase PLK3 (human) dual specificity protein kinase CLK4 (human) MAP kinase-interacting serine/threonine-protein kinase 2 (human) serine/threonine-protein kinase PAK 6 (human) SNF-related serine/threonine-protein kinase (human) serine/threonine-protein kinase 36 (human) BMP-2-inducible protein kinase (human) interleukin-1 receptor-associated kinase 4 (human) mitogen-activated protein kinase kinase kinase 20 (human) serine/threonine-protein kinase PLK2 (human) serine/threonine-protein kinase MARK1 (human) serine/threonine-protein kinase PAK 5 (human) serine/threonine-protein kinase 26 (human) eIF-2-alpha kinase GCN2 (human) phosphatidylinositol 4-kinase beta (human) serine/threonine-protein kinase 17A (human) STE20/SPS1-related proline-alanine-rich protein kinase (human) ephrin type-A receptor 6 (human) serine/threonine-protein kinase TBK1 (human) death-associated protein kinase 2 (human) ribosomal protein S6 kinase alpha-6 (human) TRAF2 and NCK-interacting protein kinase (human) serine/threonine-protein kinase tousled-like 1 (human) serine/threonine-protein kinase TAO2 (human) ALK tyrosine kinase receptor (human) serine/threonine-protein kinase ICK (human) aurora kinase C (human) calcium/calmodulin-dependent protein kinase type II subunit alpha (human) serine/threonine-protein kinase 38-like (human) microtubule-associated serine/threonine-protein kinase 1 (human) serine/threonine-protein kinase SIK3 (human) mitogen-activated protein kinase kinase kinase 2 (human) dual specificity tyrosine-phosphorylation-regulated kinase 1B (human) mitogen-activated protein kinase kinase kinase kinase 5 (human) interleukin-1 receptor-associated kinase 3 (human) serine/threonine-protein kinase 24 (human) mitogen-activated protein kinase kinase kinase 4 (human)