has_participant has participant SARS-CoV-2 S and human PPI SARS-CoV-2-human S-ACE2 direct interaction, colocalization A SARS-CoV-2 S and human PPI that has an interactor of S from SARS-CoV-2 and another interactor of ACE2 from human. direct interaction, colocalization (MI:0407, MI:0403) x-ray crystallography, pull down, unspecified method, imaging technique, protein complementation assay (MI:0114, MI:0096, MI:0686, MI:0428, MI:0090) pubmed:32132184, pubmed:888800000003, pubmed:32225176, pubmed:888800000008, pubmed:30102747, pubmed:32913273, pubmed:32313207, pubmed:888800000018, pubmed:32904601, pubmed:34029872, pubmed:32585135, pubmed:33923573, pubmed:888800000034, pubmed:32225175, pubmed:34200372, pubmed:888800000038, pubmed:32798222, pubmed:33330843, pubmed:888800000052, pubmed:33102950, pubmed:32661423, pubmed:32991842, pubmed:33607086, pubmed:33353972, pubmed:33432067, pubmed:888800000067, pubmed:33093202, pubmed:888800000069, pubmed:32970989, pubmed:888800000085, pubmed:888800000087, pubmed:33734675, pubmed:888800000105, pubmed:33707453, pubmed:34006835, pubmed:888800000119, pubmed:33432247, pubmed:33760889, pubmed:888800000124, pubmed:33310888, pubmed:888800000130, pubmed:33979123, pubmed:888800000150, pubmed:33597220, pubmed:33597251, pubmed:33417835, pubmed:888800000152, pubmed:888800000155, pubmed:34273271, pubmed:33683787, pubmed:888800000174, pubmed:888800000178, pubmed:888800000181, pubmed:33963055, pubmed:34793485, pubmed:33716040, pubmed:888800000199, pubmed:33894127, pubmed:33893398, pubmed:34373319, pubmed:34414884, pubmed:34461999, pubmed:888800000222, pubmed:888800000223, pubmed:888800000220, pubmed:888800000224, pubmed:34599882, pubmed:888800000231, pubmed:888800000233, pubmed:34287040, pubmed:34534255, pubmed:35391601, pubmed:888800000263, pubmed:888800000273, pubmed:888800000281, pubmed:34929007, pubmed:34494876, pubmed:34756892, pubmed:34543092, pubmed:34564690, pubmed:888800000301, pubmed:888800000305, pubmed:34543625, pubmed:34499924, pubmed:888800000308, pubmed:34435953, pubmed:34263709, pubmed:888800000319, pubmed:34394127, pubmed:34299155, pubmed:888800000327, pubmed:34607456, pubmed:34389878, pubmed:888800000342, pubmed:888800000348, pubmed:888800000349, pubmed:34578326, pubmed:35312342, pubmed:888800000379, pubmed:888800000380, pubmed:35136050, pubmed:35468147, pubmed:888800000387, pubmed:34927585, pubmed:34688919, pubmed:888800000391, pubmed:888800000392, pubmed:34914928, pubmed:34748603, pubmed:888800000405, pubmed:888800000406, pubmed:888800000416, pubmed:34990214, pubmed:35549549, pubmed:888800000433, pubmed:888800000446, pubmed:888800000455, pubmed:35511584, pubmed:888800000498, pubmed:888800000513, pubmed:888800000518, pubmed:888800000522, pubmed:35493476, pubmed:888800000530, pubmed:35441076, pubmed:888800000540, pubmed:888800000550, pubmed:35533762, pubmed:888800000593, pubmed:888800000600, pubmed:888800000601, pubmed:888800000602, pubmed:888800000604, pubmed:888800000620, pubmed:888800000622, pubmed:888800000624, pubmed:888800000627, pubmed:888800000633, pubmed:888800000634, pubmed:888800000635, pubmed:888800000641, pubmed:888800000650, pubmed:888800000651, pubmed:888800000665, pubmed:888800000677, pubmed:888800000681, pubmed:888800000682, pubmed:888800000689, pubmed:888800000699, pubmed:888800000724, pubmed:888800000726, pubmed:888800000727, pubmed:888800000739, pubmed:888800000745 IntAct Interaction IDs: intact:EBI-25474816|imex:IM-27821-1, intact:EBI-25475195|imex:IM-27821-17, intact:EBI-25475088|imex:IM-27821-7, intact:EBI-25475174|imex:IM-27821-15, intact:EBI-25475360|imex:IM-27816-1|wwpdb:6m0j, intact:EBI-25475468|imex:IM-27816-3, intact:EBI-25498323|imex:IM-27816-4, intact:EBI-25475491|imex:IM-27817-1, intact:EBI-25496287|imex:IM-27817-4, intact:EBI-25496356|imex:IM-27817-6, intact:EBI-25475756|wwpdb:6m17|imex:IM-27823-3|emdb:EMD-30039, intact:EBI-25495287|imex:IM-27846-1, intact:EBI-25510510|imex:IM-27912-1|wwpdb:6LZG, intact:EBI-25510579|imex:IM-27912-3, intact:EBI-25564230|imex:IM-27912-9, intact:EBI-25564253|imex:IM-27912-11, intact:EBI-25564294|imex:IM-27912-17, intact:EBI-25564364|imex:IM-27912-19, intact:EBI-25590014|imex:IM-27945-1, intact:EBI-25590118|imex:IM-27945-5, intact:EBI-25590926|imex:IM-27946-3, intact:EBI-25591046|imex:IM-27946-7, intact:EBI-25591088|imex:IM-27946-9, intact:EBI-25615509|imex:IM-28009-3, intact:EBI-25616261|imex:IM-28009-9, intact:EBI-25616746|imex:IM-28009-15, intact:EBI-25615561|imex:IM-28009-7, intact:EBI-25621587|imex:IM-28025-1, intact:EBI-25634639|imex:IM-28032-3, intact:EBI-25634661|imex:IM-28032-5, intact:EBI-25634744|imex:IM-28032-7, intact:EBI-25640134|imex:IM-28056-1, intact:EBI-25640146|imex:IM-28056-3, intact:EBI-25640180|imex:IM-28056-9, intact:EBI-25815006|imex:IM-28277-3, intact:EBI-25815051|imex:IM-28277-7, intact:EBI-25690736|imex:IM-28142-5, intact:EBI-26429900|imex:IM-28488-11, intact:EBI-26429973|imex:IM-28488-15, intact:EBI-26430082|imex:IM-28488-21, intact:EBI-25819447|imex:IM-28301-1, intact:EBI-25824800|imex:IM-28301-4, intact:EBI-25824855|imex:IM-28301-6, intact:EBI-25824927|imex:IM-28301-8, intact:EBI-25824983|imex:IM-28301-10, intact:EBI-25825007|imex:IM-28301-12, intact:EBI-25763789|imex:IM-28214-3, intact:EBI-25763818|imex:IM-28214-5, intact:EBI-25775672|imex:IM-28256-3, intact:EBI-25775687|imex:IM-28256-5, intact:EBI-25775700|imex:IM-28256-7, intact:EBI-25775712|imex:IM-28256-9, intact:EBI-25767315|imex:IM-28237-1, intact:EBI-25767399|imex:IM-28237-3, intact:EBI-25777076|imex:IM-28268-27, intact:EBI-25776364|imex:IM-28261-3, intact:EBI-25776384|imex:IM-28261-5, intact:EBI-25776417|imex:IM-28261-7, intact:EBI-25776451|imex:IM-28261-9, intact:EBI-25776495|imex:IM-28261-11, intact:EBI-25820106|imex:IM-28261-18, intact:EBI-25776535|imex:IM-28261-13, intact:EBI-25776574|imex:IM-28261-15, intact:EBI-25776619|imex:IM-28261-17, intact:EBI-25814786|imex:IM-28274-5, intact:EBI-26355600|imex:IM-28360-11, intact:EBI-26355614|imex:IM-28360-13, intact:EBI-26355627|imex:IM-28360-15, intact:EBI-26359732|imex:IM-28382-5, intact:EBI-26360443|imex:IM-28384-5, intact:EBI-26360477|imex:IM-28384-7, intact:EBI-26363662|imex:IM-28419-3, intact:EBI-26363708|imex:IM-28419-5, intact:EBI-26363745|imex:IM-28419-7, intact:EBI-26363859|imex:IM-28419-9, intact:EBI-26363911|imex:IM-28419-11, intact:EBI-26363936|imex:IM-28419-13, intact:EBI-26363972|imex:IM-28419-15, intact:EBI-26367899|imex:IM-28424-9, intact:EBI-26367908|imex:IM-28424-11, intact:EBI-26429423|imex:IM-28454-1, intact:EBI-26429436|imex:IM-28454-3, intact:EBI-26444745|imex:IM-28482-3, intact:EBI-26444763|imex:IM-28482-5, intact:EBI-25750040|imex:IM-28493-8, intact:EBI-25750050|imex:IM-28493-14, intact:EBI-25750566|imex:IM-28493-20, intact:EBI-25750578|imex:IM-28493-1, intact:EBI-25750872|imex:IM-28493-4, intact:EBI-25750941|imex:IM-28493-18, intact:EBI-26445839|imex:IM-28493-3, intact:EBI-26445871|imex:IM-28493-5, intact:EBI-26445922|imex:IM-28493-7, intact:EBI-26445950|imex:IM-28493-13, intact:EBI-26446008|imex:IM-28493-9, intact:EBI-26446035|imex:IM-28493-15, intact:EBI-26446892|imex:IM-28493-17, intact:EBI-26451852|imex:IM-28513-9, intact:EBI-26452372|imex:IM-28513-11, intact:EBI-26452398|imex:IM-28513-13, intact:EBI-26498612|imex:IM-28544-1, intact:EBI-26498665|imex:IM-28544-3, intact:EBI-26498531|imex:IM-28543-1, intact:EBI-26520251|imex:IM-28563-1, intact:EBI-26520356|imex:IM-28563-7, intact:EBI-26520364|imex:IM-28563-9, intact:EBI-26520375|imex:IM-28563-11, intact:EBI-26520384|imex:IM-28563-13, intact:EBI-26520393|imex:IM-28563-15, intact:EBI-26565413|imex:IM-28577-5, intact:EBI-26565544|imex:IM-28577-7, intact:EBI-26565367|imex:IM-28577-3|wwpdb:7df4|emdb:EMD-30661, intact:EBI-26565621|imex:IM-28577-11, intact:EBI-26592842|imex:IM-28670-23, intact:EBI-26592873|imex:IM-28670-25, intact:EBI-26595510|imex:IM-28670-19, intact:EBI-26590732|imex:IM-28672-9, intact:EBI-26591226|imex:IM-28672-23, intact:EBI-26589322|imex:IM-28631-1, intact:EBI-26589328|imex:IM-28631-3, intact:EBI-26589333|imex:IM-28631-5, intact:EBI-26589352|imex:IM-28631-7, intact:EBI-26657811|imex:IM-28752-19, intact:EBI-26687605|imex:IM-28775-1, intact:EBI-26747514|wwpdb:7L0N|imex:IM-28775-11, intact:EBI-26852270|imex:IM-28775-13, intact:EBI-26852435|imex:IM-28775-15, intact:EBI-26854343|imex:IM-28775-17, intact:EBI-26854443|imex:IM-28776-1, intact:EBI-26854690|imex:IM-28776-3, intact:EBI-26899327|imex:IM-28858-3, intact:EBI-26899350|imex:IM-28858-5, intact:EBI-26906551|imex:IM-28863-1, intact:EBI-26901164|imex:IM-28843-3, intact:EBI-26901212|imex:IM-28843-9, intact:EBI-26901565|imex:IM-28843-13, intact:EBI-26901598|imex:IM-28843-23, intact:EBI-26901615|imex:IM-28843-17, intact:EBI-26899405|wwpdb:7kj4|imex:IM-28839-1|emdb:EMD-22893, intact:EBI-26899578|imex:IM-28839-3|wwpdb:7KJ3|emdb:EMD-22892, intact:EBI-26899597|imex:IM-28839-5|wwpdb:7KJ2|emdb:EMD-22891, intact:EBI-26899635|imex:IM-28839-9, intact:EBI-26899756|imex:IM-28839-11, intact:EBI-26899776|imex:IM-28839-13, intact:EBI-26899852|imex:IM-28839-15, intact:EBI-26961684|imex:IM-28902-9, intact:EBI-26974442|wwpdb:7mjn|imex:IM-28945-1|emdb:EMD-23879, intact:EBI-26974594|wwpdb:7mjm|emdb:EMD-23878|imex:IM-28945-3, intact:EBI-26974693|imex:IM-28945-7, intact:EBI-26974739|imex:IM-28945-9, intact:EBI-26983447|imex:IM-28981-3, intact:EBI-26983765|imex:IM-28983-1, intact:EBI-26984248|imex:IM-28984-1, intact:EBI-26985053|imex:IM-29026-23, intact:EBI-26987176|imex:IM-29026-5, intact:EBI-26987551|imex:IM-29026-47, intact:EBI-26987184|imex:IM-29026-31, intact:EBI-26995399|imex:IM-29010-1, intact:EBI-26997449|imex:IM-29017-41, intact:EBI-26999023|imex:IM-29017-93, intact:EBI-27019336|imex:IM-29017-99, intact:EBI-27026467|imex:IM-29050-41, intact:EBI-27026471|imex:IM-29050-7, intact:EBI-27026741|imex:IM-29050-19, intact:EBI-27026747|imex:IM-29050-37, intact:EBI-27027688|imex:IM-29055-1, intact:EBI-27027714|imex:IM-29055-3, intact:EBI-27030807|imex:IM-29079-1, intact:EBI-27031741|imex:IM-29079-5, intact:EBI-27029955|imex:IM-29096-11, intact:EBI-27032819|imex:IM-29082-1, intact:EBI-27032851|imex:IM-29082-3, intact:EBI-27058862|imex:IM-29155-1, intact:EBI-27082167|imex:IM-29160-28, intact:EBI-27069133|imex:IM-29167-9, intact:EBI-27073227|imex:IM-29198-1, intact:EBI-27073678|imex:IM-29198-3, intact:EBI-27080483|wwpdb:7edj|emdb:EMD-31073|imex:IM-29198-7, intact:EBI-27081925|imex:IM-29231-7, intact:EBI-27090454|imex:IM-29232-13, intact:EBI-27090472|imex:IM-29232-15, intact:EBI-27090489|imex:IM-29232-17, intact:EBI-27087143|imex:IM-29220-1, intact:EBI-27086860|imex:IM-29217-1, intact:EBI-27086878|imex:IM-29217-3, intact:EBI-27086899|imex:IM-29217-5, intact:EBI-27086919|imex:IM-29217-7, intact:EBI-27086947|imex:IM-29217-9, intact:EBI-27086967|imex:IM-29217-11, intact:EBI-27086987|imex:IM-29217-13, intact:EBI-27087005|imex:IM-29217-15, intact:EBI-27087087|imex:IM-29218-1, intact:EBI-27092998|imex:IM-29240-1, intact:EBI-27095692|imex:IM-29245-1, intact:EBI-27096031|imex:IM-29247-1, intact:EBI-27123703|wwpdb:7EFR|imex:IM-29350-17, intact:EBI-27123722|wwpdb:7efp|imex:IM-29350-19, intact:EBI-27096573|imex:IM-29350-21, intact:EBI-27096989|imex:IM-29350-3, intact:EBI-27097296|imex:IM-29350-5, intact:EBI-27097439|imex:IM-29350-23, intact:EBI-27097705|imex:IM-29350-7, intact:EBI-27097775|imex:IM-29350-9, intact:EBI-27104221|imex:IM-29282-3, intact:EBI-27104297|imex:IM-29282-7, intact:EBI-27120826|imex:IM-29331-25, intact:EBI-27120852|imex:IM-29331-3, intact:EBI-27120881|imex:IM-29331-5, intact:EBI-27120906|imex:IM-29331-27, intact:EBI-27120973|imex:IM-29331-29, intact:EBI-27120996|imex:IM-29331-7, intact:EBI-27121017|imex:IM-29331-9, intact:EBI-27121034|imex:IM-29331-11, intact:EBI-27121051|imex:IM-29331-13, intact:EBI-27121068|imex:IM-29331-31, intact:EBI-27121089|imex:IM-29331-33, intact:EBI-27121112|imex:IM-29331-35, intact:EBI-27121129|imex:IM-29331-37, intact:EBI-27121151|imex:IM-29331-15, intact:EBI-27121168|imex:IM-29331-17, intact:EBI-27121183|imex:IM-29331-19, intact:EBI-27125232|imex:IM-29358-1, intact:EBI-27124888|imex:IM-29357-1, intact:EBI-27124990|imex:IM-29357-3, intact:EBI-27125034|imex:IM-29357-5, intact:EBI-27205377|imex:IM-29375-1, intact:EBI-28949794|imex:IM-29381-1, intact:EBI-28954008|imex:IM-29394-1, intact:EBI-28954024|imex:IM-29394-3, intact:EBI-28956456|imex:IM-29399-13, intact:EBI-28956391|imex:IM-29399-5, intact:EBI-28956410|imex:IM-29399-7, intact:EBI-28957613|imex:IM-29405-3, intact:EBI-28957653|imex:IM-29405-5|wwpdb:7vxc|emdb:EMD-32175|wwpdb:7VX9|wwpdb:7vxa|emdb:EMD-32172|emdb:EMD-32173|wwpdb:7vxb|emdb:EMD-32174, intact:EBI-28963378|imex:IM-29405-7|wwpdb:7vx5|emdb:EMD-32169, intact:EBI-28963480|wwpdb:7vxd|emdb:EMD-32176|imex:IM-29405-11|emdb:EMD-32184|wwpdb:7vxk|emdb:EMD-32182|wwpdb:7vxf|emdb:EMD-32178|wwpdb:7vxm, intact:EBI-28963715|imex:IM-29405-13|wwpdb:7vx4|emdb:EMD-32168, intact:EBI-28965353|imex:IM-29407-3|wwpdb:7SXX|emdb:EMD-25509, intact:EBI-28965416|imex:IM-29407-5|wwpdb:7SXY|emdb:EMD-25510, intact:EBI-28965473|imex:IM-29407-7|wwpdb:7SY5|emdb:EMD-25517, intact:EBI-28965550|imex:IM-29407-9, intact:EBI-30814248|imex:IM-29439-17, intact:EBI-30814186|imex:IM-29439-25, intact:EBI-30814198|imex:IM-29439-11 BioGRID Interaction IDs: biogrid:2652693, biogrid:2658248, biogrid:2658283, biogrid:2658319, biogrid:2658331, biogrid:2658332, biogrid:2661833, biogrid:2691134, biogrid:2691135, biogrid:2692808, biogrid:2693234, biogrid:2693238, biogrid:2693239, biogrid:2693275, biogrid:2745986, biogrid:2751460, biogrid:2751466, biogrid:2766899, biogrid:2766900, biogrid:2766905, biogrid:2766908, biogrid:2766909, biogrid:2768150, biogrid:2768153, biogrid:2768154, biogrid:2768156, biogrid:2768192, biogrid:2768193, biogrid:2768194, biogrid:2771545, biogrid:2788353, biogrid:2788355, biogrid:2788936, biogrid:2789204, biogrid:2822306, biogrid:2822314, biogrid:2822328, biogrid:2822329, biogrid:2822333, biogrid:2822334, biogrid:2881697, biogrid:2881698, biogrid:2881722, biogrid:2881724, biogrid:2885395, biogrid:2886813, biogrid:2887319, biogrid:2887326, biogrid:2890014, biogrid:2890022, biogrid:2890584, biogrid:2890828, biogrid:2892819, biogrid:2892839, biogrid:2900406, biogrid:2901370, biogrid:2901371, biogrid:2901372, biogrid:2901471, biogrid:2901485, biogrid:2901488, biogrid:2901509, biogrid:2901510, biogrid:2908084, biogrid:2908099, biogrid:2908101, biogrid:2908102, biogrid:2908103, biogrid:2908125, biogrid:2908132, biogrid:2908364, biogrid:2908366, biogrid:2908662, biogrid:2932231, biogrid:2932324, biogrid:2932819, biogrid:2936975, biogrid:2936976, biogrid:2936982, biogrid:2936983, biogrid:2970773, biogrid:2970834, biogrid:2971131, biogrid:2971812, biogrid:2971813, biogrid:2971814, biogrid:3012408, biogrid:3012409, biogrid:3012410, biogrid:3012412, biogrid:3012416, biogrid:3012417, biogrid:3012418, biogrid:3012436, biogrid:3012451, biogrid:3012455, biogrid:3012459, biogrid:3012460, biogrid:3015389, biogrid:3015396, biogrid:3015401, biogrid:3015402, biogrid:3021793, biogrid:3021835, biogrid:3026247, biogrid:3026349, biogrid:3026350, biogrid:3026401, biogrid:3026403, biogrid:3196708, biogrid:3196724, biogrid:3196833, biogrid:3196941, biogrid:3196948, biogrid:3200039, biogrid:3200045, biogrid:3200048, biogrid:3201578, biogrid:3201868, biogrid:3201880, biogrid:3201883, biogrid:3201886, biogrid:3217393, biogrid:3217463, biogrid:3308053, biogrid:3309929, biogrid:3309930, biogrid:3310207, biogrid:3310209, biogrid:3310210, biogrid:3310216, biogrid:3323068, biogrid:3323069, biogrid:3324977, biogrid:3324979, biogrid:3324990, biogrid:3325978, biogrid:3339915, biogrid:3339972, biogrid:3339977, biogrid:3339978, biogrid:3339979, biogrid:3383433, biogrid:3383434, biogrid:3383437, biogrid:3383461, biogrid:3383466, biogrid:3395535, biogrid:3395984, biogrid:3395987, biogrid:3396025, biogrid:3399794, biogrid:3399795, biogrid:3400998, biogrid:3401409, biogrid:3401471, biogrid:3404333, biogrid:3407299, biogrid:3407401, biogrid:3454821, biogrid:3454823, biogrid:3454857, biogrid:3458138, biogrid:3458139, biogrid:3458244 ZW, SP, GH, YH spike glycoprotein (SARS-CoV-2) angiotensin-converting enzyme 2 (human)