has_participant has participant protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane GO:0006614 SRP-dependent cotranslational protein-membrane targeting biological_process ER translocation SRP-dependent cotranslational membrane targeting The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. protein targeting to ER 60S ribosomal protein L3 (human) 60S ribosomal protein L13a (human) 60S ribosomal protein L15 (human) 60S ribosomal protein L37 (human) 60S ribosomal protein L23a (human) 60S ribosomal protein L23 (human) 60S ribosomal protein L11 (human) 60S ribosomal protein L8 (human) 60S ribosomal protein L19 (human) 60S ribosomal protein L26-like 1 (human)