has_participant has participant signal transduction signaling cascade signal transduction by conformational transition signalling pathway GO:0023033 GO:0007165 signaling pathway biological_process signalling cascade Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. GO:0023014 GO:0023016 GO:0023015 signal transduction by cis-phosphorylation signal transduction by protein phosphorylation The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. Wikipedia:Signal_transduction signal transduction by trans-phosphorylation GO:0023045 cellular process regulation of cellular process hematopoietic prostaglandin D synthase (human) nuclear receptor subfamily 1 group I member 2 (human) pro-opiomelanocortin (human) estrogen receptor (human) annexin A1 (human) glucocorticoid receptor (human) progesterone receptor (human) macrophage colony-stimulating factor 1 receptor (human) tyrosine-protein kinase Lyn (human) muscarinic acetylcholine receptor M4 (human) mineralocorticoid receptor (human) fibroblast growth factor 2 (human) platelet-derived growth factor receptor beta (human) androgen receptor (human) mast/stem cell growth factor receptor Kit (human) muscarinic acetylcholine receptor M1 (human) breakpoint cluster region protein (human) cyclin-dependent kinase 4 (human) proto-oncogene tyrosine-protein kinase Src (human) sphingomyelin phosphodiesterase (human) muscarinic acetylcholine receptor M3 (human) gamma-aminobutyric acid receptor subunit beta-3 (human) tyrosine-protein kinase receptor UFO (human) alpha-1A adrenergic receptor (human) serine/threonine-protein kinase mTOR (human) tyrosine-protein kinase ABL2 (human) guided entry of tail-anchored proteins factor CAMLG (human) dual specificity mitogen-activated protein kinase kinase 1 (human) 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (human) mitogen-activated protein kinase 14 (human) estrogen receptor beta (human) ALK tyrosine kinase receptor (human)