has_participant has participant cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. GO:0007169 biological_process transmembrane receptor protein tyrosine kinase signalling pathway high affinity nerve growth factor receptor (human) tyrosine-protein kinase Lck (human) tyrosine-protein kinase Fyn (human) macrophage colony-stimulating factor 1 receptor (human) tyrosine-protein kinase Yes (human) tyrosine-protein kinase Lyn (human) tyrosine-protein kinase Fgr (human) mast/stem cell growth factor receptor Kit (human) receptor-type tyrosine-protein kinase FLT3 (human) tyrosine-protein kinase CSK (human) tyrosine-protein kinase ABL2 (human) tyrosine-protein kinase FRK (human) tyrosine-protein kinase BTK (human) epithelial discoidin domain-containing receptor 1 (human) ALK tyrosine kinase receptor (human)