has_participant has participant G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger G protein signalling, coupled to cyclic nucleotide second messenger GPCR signaling pathway via cyclic nucleotide second messenger G-protein signalling, coupled to cyclic nucleotide second messenger G protein signaling, coupled to cyclic nucleotide second messenger G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. biological_process annexin A1 (human) muscarinic acetylcholine receptor M2 (human) D(1A) dopamine receptor (human) histamine H2 receptor (human) 5-hydroxytryptamine receptor 7 (human) mu-type opioid receptor (human) delta-type opioid receptor (human) 5-hydroxytryptamine receptor 6 (human)