has_participant has participant cell-cell signaling chemical synaptic transmission signal transmission across a synapse GO:0007268 synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. biological_process Wikipedia:Neurotransmission neurotransmission glycine receptor subunit alpha-3 (human) 5-hydroxytryptamine receptor 1A (human) D(1B) dopamine receptor (human) sodium-dependent noradrenaline transporter (human) 5-hydroxytryptamine receptor 2A (human) 5-hydroxytryptamine receptor 2C (human) sodium-dependent serotonin transporter (human) 5-hydroxytryptamine receptor 7 (human) mu-type opioid receptor (human) delta-type opioid receptor (human) kappa-type opioid receptor (human) 5-hydroxytryptamine receptor 2B (human) 5-hydroxytryptamine receptor 6 (human) chromaffin granule amine transporter (human) synaptic vesicular amine transporter (human)