cystic fibrosis transmembrane conductance regulator CFTR PR:000001044 channel conductance-controlling ATPase protein Category=gene. Note: The open conformation of the CFTR channel is stabilized via interaction of its N-terminal region with other proteins, most notably filamin. [PRO:DAN, PMID:29779042] ATP-binding cassette transporter sub-family C member 7 A chloride channel protein that is a translation product of the human CFTR gene or a 1:1 ortholog thereof. Involved in the transport of chloride ions. The characteristic domain composition of the functional isoform consists of two modules of a membrane-spanning domain (ABC transporter transmembrane region) followed by a nucleotide-binding domain (ABC transporter domains), separated by an intracellular regulatory domain (R-domain). It also contains a C-terminal PDZ-binding region. The R-domain is an inhibitory domain of CFTR, and phosphorylation of the R-domain removes this inhibition, allowing activation of chloride flux. ABCC7 PIRSF:PIRSF002777 cAMP-dependent chloride channel IUPHARobj:707 ATP-binding cassette sub-family C member 7 chloride channel protein