frizzled-like G-protein coupled receptor Category=family. Classification based on GRAFS system. [PMID:12761335] A G-protein coupled receptor with core architecture consisting of an Fz domain (Pfam:PF01392), also known as Frizzled CRD (cysteine rich domain), followed by a Frizzled/Smoothened family membrane region (Pfam:PF01534), which includes 7 transmembrane helices, and a cytoplasmic domain containing the motif Lys-Thr-x-x-x-Trp. They generally function as cell-surface receptors for Wnts. fam:frizzled IUPHAR:GPCRListForward?class=frizzled PIRSF:PIRSF006696 class F G-protein coupled receptor protein IUPHARfam:25 PR:000001315 G-protein coupled receptor