has part has part has_part angiotensin-converting enzyme angiotensin-converting enzyme 2 multicellular anatomical structure renin-angiotensin system renin angiotensin aldosterone system uberon FMA:74787 MESH:G06.535.805 renin angiotensin system renin-angiotensin system A system consisting of renin, angiotensin-converting enzyme, and angiotensin II. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming angiotensin I. The converting enzyme contained in the lung acts on angiotensin I in the plasma converting it to angiotensin II, the most powerful directly pressor substance known. It causes contraction of the arteriolar smooth muscle and has other indirect actions mediated through the adrenal cortex. may be replaced by a GO process in future UBERON:0018229 renin-angiotensin-aldosterone system