chemical inhibits protein has role has role nitrile pyrazoles inhibitor antineoplastic agent pyrrolopyrimidine ruxolitinib PMID:22399854 chebi_ontology PMID:22544377 PMID:22281165 306.15929 PMID:22279053 Wikipedia:Ruxolitinib CAS:941678-49-5 PMID:21919691 PMID:22034658 Reference: PMID: 22037378 PMID:22830345 Patent:US2010190981 Drug_Central:4190 Patent:US2008312258 PMID:22474318 Reaxys:18703668 PMID:22375970 PMID:22375971 ruxolitinib CHEBI:66919 LINCS:LSM-1139 306.36500 HFNKQEVNSGCOJV-OAHLLOKOSA-N PMID:21926964 N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 INCB018424 PMID:21602517 A pyrazole substituted at position 1 by a 2-cyano-1-cyclopentylethyl group and at position 3 by a pyrrolo[2,3-d]pyrimidin-4-yl group. Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis. (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1 PMID:22227528 PMID:22422826 PMID:22718840 KEGG:D09959 C17H18N6 0 EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor serine/threonine-protein kinase MARK2