capable of megakaryocyte-erythroid progenitor cell megakaryocyte/erythrocyte progenitor colony forming unit erythroid megakaryocyte CFU-EM megakaryocyte/erythroid progenitor cell MEP Meg/E progenitor ZFA:0009022 CFU-MegE https://cellxgene.cziscience.com/cellguide/CL_0000050 megakaryocyte-erythroid progenitor cell MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2. The megakaryocyte-erythroid progenitor (MEP) cell belongs to the multipotent hematopoietic progenitor cells, which can give rise to multiple different cell types. They are found in the bone marrow, the primary organ where new blood cells are generated. MEPs are specially programmed to develop into two distinct blood cell lineages, namely megakaryocytes, which go on to produce platelets for blood clotting, and the erythroid lineage which consists of red blood cells responsible for oxygen transport in the body. The MEP cells are the result of a decision-making process within the hematopoietic stem cell population. Hematopoietic stem cell can differentiate into multiple types of progenitor cells, including myeloid progenitor cells. A further subdivision within this myeloid lineage generates the MEP cells. Therefore, these megakaryocyte-erythroid progenitors represent a key juncture between hematopoietic stem cells and mature blood cell types in the myeloid lineage. Megakaryocyte-erythroid progenitor cells play a crucial role in the homeostasis of some of the most crucial constituents of blood. The megakaryocytes produced from these bipotent progenitor cells contribute to hemostasis by producing platelets - small anucleated fragments that are pivotal for blood clotting and preventing bleeding. Similarly, the erythroid lineage from MEP cells gives rise to erythrocytes, which harbor hemoglobin, the molecule that transports oxygen from lungs to every nook and corner of the body. An imbalance or malfunction in MEP function thus can significantly impact human health, leading to diseases like thrombocytopenia or anemia. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) A progenitor cell committed to the megakaryocyte and erythroid lineages. granulocyte monocyte progenitor cell myeloid cell macrophage dendritic cell progenitor hematopoietic oligopotent progenitor cell progenitor cell erythrocyte differentiation megakaryocyte differentiation Homo sapiens