part of part of Sertoli cell Sertoli cells, also known as sustentacular cells, are epithelial cells that play a crucial part of the male reproductive system and are situated within the seminiferous tubules of the testes. Functionally, Sertoli cells play diverse and pivotal roles in supporting spermatogenesis, the intricate process of sperm production. To scaffold the developing sperm cells, Sertoli cells morphologically change, interacting directly with the germ cells to provide nutritional support, metabolic regulation, and waste removal, thereby creating an environment conducive to the development of germ cells. In addition to their structural function, Sertoli cells also secrete several bioactive molecules with crucial implications for spermatogenesis. These include anti-mullerian hormone (AMH) during fetal life, inhibin, and androgen binding protein (ABP), as well as several growth factors and transport proteins. They also contribute to the immune-privileged status of the testes by forming the blood-testis barrier, safeguarding sperm antigens from the systemic immune response. Given their extensive roles in maintaining testicular function, impairments in Sertoli cell function can lead to male infertility and are implicated in a range of related disorders. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier. FMA:72298 ZFA:0009133 CALOHA:TS-0922 VHOG:0001348 BTO:0001238 https://cellxgene.cziscience.com/cellguide/CL_0000216 androgen binding protein secreting cell supporting cell seminiferous tubule epithelial cell secretory epithelial cell seminiferous tubule of testis