has part lacks_plasma_membrane_part has plasma membrane part develops from neutrophilic myelocyte neutrophilic metamyelocyte ZFA:0009268 These cells are also CD35-negative, CD49d-positive, and fMLP receptor-negative. They are found in the Band 2 fraction. A neutrophil precursor in the granulocytic series, being a cell intermediate in development between a myelocyte and the band form neutrophil. The protein synthesis seen in earlier stages decreases or stops; the nucleus becomes indented where the indentation is smaller than half the distance to the farthest nuclear margin; chromatin becomes coarse and clumped; specific granules predominate while primary granules are rare; and the cytoplasm becomes amphophilic like that of a mature granulocyte. This cell type is integrin alpha-M-positive, CD13-negative, CD15-positive, CD16-positive, CD33-positive, CD24-positive, fMLP receptor-negative and has expression of C/EBP-a, C/EBP-e, PU.1 transcription factor, lactotransferrin, myeloperoxidase and neutrophil gelatinase associated lipocalin. juvenile neutrophil FMA:84197 immature neutrophil metamyelocyte acidophilic cytoplasm reniform nucleus heterochromatin azurophil granule tertiary granule integrin alpha-M alpha-(1,3)-fucosyltransferase 4 low affinity immunoglobulin gamma Fc region receptor III fMet-Leu-Phe receptor CD33 molecule signal transducer CD24 transcription factor PU.1 aminopeptidase N CCAAT/enhancer-binding protein alpha CCAAT/enhancer-binding protein epsilon neutrophil gelatinase-associated lipocalin lactotransferrin myeloperoxidase