blood_and_immune_upper_slim has plasma membrane part granulocyte eosinophil eosinocyte Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte. BTO:0000399 polymorphonuclear leucocyte eosinophilic leukocyte eosinophilic leucocyte eosinophilic granulocyte https://cellxgene.cziscience.com/cellguide/CL_0000771 Eosinophils are a type of granulocyte derived from myeloid progenitors in the bone marrow; they are a part of the body's immune system. Named for their affinity to eosin, a red acidic dye used in staining procedures, eosinophils contribute to the immune system's response by migrating to inflammation sites, particularly those produced by allergic reactions and infections due to multicellular parasites. They comprise ~1-5% of the white blood cells in circulation. Eosinophils play crucial roles in mediating inflammatory responses. They carry granules containing a variety of enzymes and proteins, including major basic protein (MBP), eosinophil peroxidase (EPO), eosinophil cationic protein (ECP), and eosinophil-derived neurotoxin (EDN). These enzymes and proteins are effective in killing bacteria, parasites, and some cancer cells. When exposed to an antigen, eosinophils degranulate and release these mediators to the site of infection, resulting in the destruction of invading microorganisms. Specifically, in parasitic infections, eosinophils attach themselves to the parasites and release these cytotoxic granules, causing a lethal rupture in the parasite's surface. Eosinphils may also release cytokines to attract other immune cells to sites of infection and to skew the response towards type 2 immunity. Eosinophils are also involved in conditions such as asthma and allergic reactions. They secrete chemical mediators such as leukotrienes and prostaglandins that trigger contraction of smooth muscles, causing symptoms such as bronchoconstriction observed in asthma. However, these multifunctional cells, while useful in defending the body, may also inadvertently cause tissue damage if excessively activated. Increased numbers of eosinophils, a condition known as eosinophilia, can indicate a variety of diseases including allergies, skin disorders, parasitic and fungal infections, autoimmune diseases, certain types of cancer, and asthma. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive. CALOHA:TS-0279 FMA:62861 MESH:D004804 polymorphonuclear leukocyte C-C chemokine receptor type 1 C-C chemokine receptor type 3 CD44 molecule CD69 molecule CD9 molecule