has part develops from neutrophilic promyelocyte neutrophil immature neutrophil ZFA:0009328 immature neutrocyte immature neutrophilic leucocyte immatuer neutrophilic leukocyte immature neutrophil leucocyte immature neutrophil leukocyte https://cellxgene.cziscience.com/cellguide/CL_0000776 Any of the immature forms of a neutrophil in which neutrophilic specific granules are present but other phenotypic features of the mature form may be lacking. An immature neutrophil, also known as a band neutrophil or band cell, is an intermediary stage in neutrophilic granulocyte development. Immature neutrophils are formed in the bone marrow then released into the bloodstream where they eventually mature into functional, mature segmented neutrophils. They are characterized by an unsegmented, curved nucleus, a distinguishing factor that differentiates them from mature neutrophils, which possess a multi-lobed nucleus. Immature neutrophils can be found in circulation, but their numbers may increase drastically during infection. These cells are released from the bone marrow as a result of emergency granulopoiesis. The role of these cells in infection and acute inflammation remains controversial, and it has been suggested that these cells could possess immunosuppressive or proinflammatory activity. An increase of immature neutrophils in the bloodstream, a condition referred to as bandemia or a left shift, can be an important clinical indicator. While low-level presence is typical, an abnormally high count can signal severe or systemic bacterial infection, inflammation, or less commonly, diseases that affect bone marrow function such as leukemia. However, not all bacterial infections will result in a left shift. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) alobate nucleus