has_not_completed lacks_plasma_membrane_part has plasma membrane part mature B cell naive B cell This cell type is compatible with the HIPC Lyoplate markers for 'naive B cell'. Per DSD: Naive B cells are also reportedly CD10-negative, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD25-negative, CD27-negative, CD34-negative, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD80-negative, CD81-positive, CD84-positive, CD86-negative, CD95-negative, CD138-negative, CD150-positive, CD184/CXCR4-positive, CD185/CXCR5-positive, CD196/CCR6-positive, CD200-positive, CD229-positive, CD243-positive, CD289-positive, CD290-positive, CD352-positive, MHCII/HLA-DR-positive, cadherin 9-positive, and sIgH-positive, Transcription factors: Pax5-positive, ETS1-positive, FOXO1A-positive, KLF4-positive, KLF9-positive, MiTF-positive, OBF1-positive, PLZF-positive, and SpiB-positive. https://cellxgene.cziscience.com/cellguide/CL_0000788 naive B-lymphocyte A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery. ZFA:0009334 Naïve B cells are mature B lymphocytes that have not previously encountered a specific antigen, implying that they are "naïve" or "inexperienced". They express B-cell receptors (BCRs) on the cell surface that enable them to detect specific foreign antigens. Due to the high variability of BCRs even within the same individual, each naïve B cell is capable of recognizing a unique molecular structure, leading to an immensely diverse repertoire of these cells ready to react against a wide array of pathogenic threats. They are critical for humoral immunity as they are the precursors of antigen-specific B cells, giving rise to effector cells or memory B cells after antigen encounter and activation. The primary function of naïve B cells involves recognizing foreign antigens and initiating the immune response. If the B-cell receptor-engaged naïve B cell receives a proper activation signal from a helper T cell, it begins to proliferate and differentiate into plasma cells and memory B cells. Plasma cells secrete antibodies that neutralize the antigen, whereas memory B cells provide long-term immunity by remembering the specific pathogen for quicker attack upon any future invasions by the same entity. Furthermore, naïve B cells play a crucial role in the establishment of germinal centers (GCs), which are special zones within secondary lymphoid organs where mature B cells undergo clonal expansion, antibody class switching, and somatic hypermutation for the production of high-affinity antibodies. The maturation and changes within these GCs not only enhance the body's defense mechanisms against ongoing infections, but also promise a more rapid and effective response during subsequent encounters with the same pathogen. In summary, naïve B cells represent a stage in B cell development and serve as foundations for the adaptive humoral immune response, playing pivotal roles in antigen recognition, initiation of immune response, and long-term immunological memory. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) naive B-cell naive B lymphocyte B cell affinity maturation IgD immunoglobulin complex IgM immunoglobulin complex Homo sapiens membrane-spanning 4-domains subfamily A member 1 CD27 molecule