has plasma membrane part capable of has low plasma membrane amount CD4-positive, alpha-beta T cell CD4-positive, CD25-positive, alpha-beta regulatory T cell suppressor T lymphocyte A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release. CD4-positive, CD25-positive, alpha-beta regulatory T-cell suppressor T cell CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte This cell type is compatible with the HIPC Lyoplate markers for 'Treg'. The inclusion of CD127lo in the logical definition is compatible with both human and mouse T cells of this subtype. The CD4-positive, CD25-positive, alpha-beta regulatory T (Treg) cell serves as a vital element in the mammalian immune system, playing a pivotal role in maintaining immune homeostasis and preventing autoimmunity. This particular T regulatory cell is characterized by CD4 proteins and a high level of CD25 (the alpha chain of the interleukin-2 receptor) on its cell surface. The T-cell receptor (TCR) of these Treg cells is composed of alpha and beta protein chains, making them a subtype of the alpha-beta T cell population that recognize and bind to antigens presented by MHC class II molecules. The primary function of CD4-positive, CD25-positive, alpha-beta Treg cells is regulating immune responses, ensuring that the immune response is proportionate and preventing autoimmunity, maintaining peripheral immune tolerance, and limiting chronic inflammation. They achieve this regulation by suppressing or downregulating the proliferation of effector immune cells, which are activated in response to antigens, to prevent their excessive or uncontrolled activity. CD4-positive, CD25-positive, alpha-beta Treg cells can suppress immune responses via a variety of mechanisms, including the release of inhibitory cytokines, in particular IL-10 and TGFβ, or through cytolysis of effector immune cells (e.g. antibody-producing B cells) involving perforin and granzymes. They can also modulate the maturation or function of dendritic cells, which are key antigen-presenting cells, and thereby reduce their ability to stimulate effector T cells. This downregulation also suppresses effector T cell functions against self-antigens—proteins that are innate to the body—to prevent autoimmunity. In essence, Treg cells act as a policing force within the immune system to maintain balance and prevent overreaction which can potentially lead to damaging effects. Besides their crucial role in preventing autoimmunity, CD4-positive, CD25-positive, alpha-beta Treg cells contribute to other functions such as tumor immune evasion, maternal-fetal tolerance, and transplantation tolerance. By suppressing the cytotoxic T cell response, these cells may inadvertently help tumor cells evade destruction, contributing to cancer progression. However, this characteristic can be potentially manipulated for therapeutic applications in immune-related diseases or transplantation, further highlighting the potential and importance of CD4-positive, CD25-positive, alpha-beta regulatory T cells in immune regulation. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) suppressor T-lymphocyte Treg suppressor T-cell CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte https://cellxgene.cziscience.com/cellguide/CL_0000792 regulatory T cell negative regulation of immune response interleukin-2 receptor subunit alpha interleukin-7 receptor subunit alpha