produces lymphocyte of B lineage antibody secreting cell A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin. https://cellxgene.cziscience.com/cellguide/CL_0000946 Antibody secreting cells, such as short-lived plasmablasts and long-lived plasma cells, form a key component of the adaptive immune system. These cells originate from B-lymphocytes upon exposure to antigens. They are primarily characterized by their capacity to produce and secrete large amounts of antibodies (immunoglobulins) that help to neutralize the pathogens, defining the primary role of these cells in the humoral immune response. Antibody secreting cells are found predominantly within the lymph nodes, spleen, and mucosa-associated lymphoid tissues. They are characterized by an extensive rough endoplasmic reticulum, reflecting the high antibody production. The interesting dynamics of these cells, switching from a nonsecreting, antigen-specific B-cell state to a high-rate immunoglobulin-secreting cell state, is a major factor in sustaining an effective adaptive immune system: Derived from a single clone, the secreted immunoglobulins have a unique antigen specificity inherited from the parent B cell. They are able to recognize specific extracellular antigens, aiding in marking harmful invaders such as viruses and bacteria for elimination, either by direct neutralization or by recruiting other immune cells for assistance. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) immunoglobulin complex, circulating