capable of innate lymphoid cell group 1 innate lymphoid cell 2017-01-30T20:42:44Z https://cellxgene.cziscience.com/cellguide/CL_0001067 An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines. Group 1 Innate lymphoid cells (ILC1s) are one of five subsets of innate lymphoid cells (ILCs). ILC1s are largely tissue-resident cells and express the transcription factor T-bet and predominantly produce the cytokine interferon-gamma (IFN-γ). ILC1s initially included natural killer (NK) cells and T-bet+ ILC1s, but a 2018 update to the nomenclature proposed to further separate these two cell types based upon differences in development and function. However, it can be difficult to distinguish between these cell types. ILC1s are non-cytotoxic or weakly cytotoxic, expressing relatively low levels of perforin, and play an important role in the response to viruses, certain intracellular bacteria and parasites, and fungi. Their release of IFN-γ and tumor necrosis factor (TNF) further shapes the adaptive immune response. Their functionality mirrors Th1 helper cells. While ILC1s have been shown to be important in the response to infections, ILC1s have also been demonstrated to accumulate in inflammatory diseases such as Crohn’s disease, chronic obstructive pulmonary disease, and rheumatoid arthritis. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) type II interferon production