part of part of has characterizing marker set NS forest marker set of pulmonary interstitial fibroblast (Human lung). fibroblast pulmonary interstitial fibroblast 2010-09-07T02:29:38Z FMA:84467 A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis. Pulmonary interstitial fibroblasts, or lung fibroblasts, are a specific type of cell located within the lungs. They are predominantly located in the connective tissue or interstitial space of the lung that is in close proximity to the alveolar epithelium and pulmonary capillaries. These cells play a crucial role in maintaining lung structure and function through the synthesis and remodeling of the extracellular matrix, which provides structural support to the lung tissues. These cells ensure effective gas exchange by providing a scaffold for the epithelial structure. In addition to providing support, the extracellular matrix acts as a binding site for various molecules that can directly influence cell behavior and the local microenvironment. Fibroblasts not only secrete the extracellular matrix themselves but also have the capacity to remodel the matrix by producing matrix metalloproteinases (MMPs). This ability of synthesis and degradation makes fibroblasts essential for normal lung homeostasis and repair following lung injury. Under pathological conditions such as pulmonary fibrosis, the function of pulmonary interstitial fibroblasts becomes deregulated. They become overly active and produce excess extracellular matrix, notably collagen, resulting in the thickening and stiffening of lung tissues that compromise its function. Furthermore, these cells can transform into myofibroblasts, cells that are more active in producing matrix proteins and contribute to scar formation or fibrosis. Understanding the biology and regulation of pulmonary interstitial fibroblasts is thus essential for devising therapeutic strategies for diseases characterized by abnormal tissue remodeling and fibrosis, such as idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease (COPD). (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) pulmonary myofibroblast pulmonary septal cell The marker set DPT, APOD can identify the Human cell type pulmonary interstitial fibroblast in the lung with a confidence of 0.58 (NS-Forest FBeta value). https://cellxgene.cziscience.com/cellguide/CL_0002241 interstitial cell Homo sapiens respiratory system interstitial tissue