peptide hormone secreting cell type L enteroendocrine cell 2010-09-10T03:59:09Z The type L enteroendocrine cell, also known as L-cell, is an integral part of the digestive system found in the intestine, primarily identified in the ileum and colon. These cells are distinguished among other cell types primarily because of their role in the secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). Both peptides are essential for maintaining the body's energy homeostasis and the normal functioning of the gastrointestinal tract. In response to the ingestion of food, type L enteroendrocrine cells secrete GLP-1, a potent hormone that stimulates insulin secretion, lowers glucagon secretion, slows gastric emptying, enhances satiety, and has the potential to promote proliferation of type B pancreatic cells and improve their function. L-cells also secrete peptide YY (PYY), which plays a pivotal role in controlling appetite. Postprandially secreted into the bloodstream, PYY functions by decreasing appetite and food intake, thereby contributing to long-term energy balance. PYY can centralize the regulation of appetite via the hypothalamus. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) A enteroendocrine cell type that is numerous in ileum, present in jejunum and large intestine, few in duodenum. This cell type produces glucagon-like immunoreactants (glicentin, glucagon-37, glucagon-29, GLP-1 and -2) and PYY. FMA:62944 https://cellxgene.cziscience.com/cellguide/CL_0002279 intestinal enteroendocrine cell