has plasma membrane part conventional dendritic cell CD11b-positive dendritic cell 2010-11-23T01:50:05Z CD11b-positive dendritic cells are a subset of conventional dendritic cells, which express the myeloid antigen CD11b. They play an important role in the recognition, uptake, processing, and presentation of antigens to T cells, thereby bridging innate and adaptive immunity. CD11b+ dendritic cells are the most abundant conventional dendritic cells in lymphoid organs (except for the thymus). Their MHC presentation and migration is dependent on IRF4, although the importance of IRF4 for the development of CD11b+ is still under debate. They represent a heterogeneous subset of dendritic cells, which includes epidermal Langerhans cells, dermal and interstitial dendritic cells. Given their heterogeneity, the specific functions of CD11b+ dendritic cells are difficult to assign. They exhibit strong expression of MHC-II presentation complexes and thereby play an important role in the induction of CD4+ T cell immunity. CD11b+ dendritic cells can also be characterized by their production of cytokines, such as IL-6 and IL-23, and splenic CD11b+ dendritic cells have been shown to produce proinflammatory chemokines, such as CCL3, CCL4, and CCL5, following TLR ligand exposure. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) A conventional dendritic cell that expresses CD11b (ITGAM). https://cellxgene.cziscience.com/cellguide/CL_0002465 integrin alpha-M