part of part of goblet cell epithelial cell of tracheobronchial tree respiratory tract goblet cell tracheobronchial goblet cell 2020-05-07T18:14:52Z goblet cell of tracheobronchial tree Tracheobronchial goblet cells, named for their goblet-like shape, are specialized cells mainly found in the respiratory tract, including the trachea and bronchial tubes. Positioned among ciliated epithelial cells, they play a crucial role in the respiratory system's defense against particles and pathogens. These cells, akin to mucus-producing factories, secrete a viscous fluid primarily composed of mucin proteins. Their principal function is to create a protective layer over the respiratory tract's epithelial surfaces. This layer acts as the first line of defense by trapping dust, microbes, allergens, and foreign particles, preventing them from reaching the lungs' deeper, more sensitive areas. The mucus layer also supports proper cilia function and surface lubrication. In addition to their protective role, tracheobronchial goblet cells contribute to immune regulation in the lungs. When pathogens are detected, they signal specific immune cells to enhance the lung's immune response. However, conditions like chronic bronchitis, asthma, or cystic fibrosis may lead to goblet cell overproduction of mucus, potentially obstructing airways. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) Any goblet cell that is part of the tracheobronchial epithelium. https://cellxgene.cziscience.com/cellguide/CL_0019003 tracheobronchial epithelium