part of part of hepatocyte centrilobular region hepatocyte 2020-10-12T11:03:51Z Centrilobular region hepatocytes, also referred to as perivenous or pericentral hepatocytes, are specialized cells that constitute the largest component of the liver. These cells are strategically arranged around the central vein of a liver lobule, forming the zone 3 region. This unique location is critically significant for their distinctive functional capabilities, making them different from periportal hepatocytes of zone 1 and midzonal hepatocytes of zone 2. One of the primary functions of centrilobular region hepatocytes is linked to the body’s metabolic detoxification processes. These cells are predominantly involved in xenobiotic biotransformation, assisting with the metabolism and excretion of foreign substances, such as drugs or harmful toxins. This role is facilitated by their ability to express high levels of Cytochrome P450 enzymes, which are pivotal in phase I detoxification reactions. Additionally, centrilobular region hepatocytes also play a crucial role in bile acid synthesis and the biotransformation of endogenous compounds such as steroids, fatty acids, and bilirubin. Being situated in zone 3, centrilobular hepatocytes are more susceptible to hypoxic injury than other hepatocytes due to the lower oxygen supply. Furthermore, due to their central role in detoxification, they are particularly prone to drug-induced hepatic damage. (This extended description was generated by ChatGPT and reviewed by the CellGuide team, who added references, and by the CL editors, who approved it for inclusion in CL. It may contain information that applies only to some subtypes and species, and so should not be considered definitional.) Any hepatocyte that is part of the liver lobule centrilobular region. These cells are the primary location for the biotransformation of drugs. centrilobular hepatocyte https://cellxgene.cziscience.com/cellguide/CL_0019029 liver lobule centrilobular region