part of part of capable of stem cell eukaryotic cell osteochondral skeletal stem cell 2025-11-27T00:00:00Z A tissue-specific stem cell with long-term self-renewal capacity that is restricted to generating bone, cartilage, and stromal cell lineages. This cell is primarily located in the growth plate (resting zone), periosteum, and subchondral bone regions, and is marked by high clonogenicity and robust multipotent differentiation potential in both osteogenic and chondrogenic lineages. Distinctively, ocSSC lacks adipogenic capacity, distinguishing it from other mesenchymal stem cell populations. ocSSC GitHub Copilot osteoblast differentiation cartilage development skeletal system